Post-translational modifications of tubulin: pathways to functional diversity of microtubules.
Post-translational modifications of tubulin: pathways to functional diversity of microtubules.
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DOI：
10.1016/j.tcb.2014.10.004
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发表时间：
2015-03
影响因子：
19
通讯作者：
Brady, Scott T.
中科院分区：
文献类型：
--
作者：
Song, Yuyu;Brady, Scott T.
微管蛋白和微管受到大量翻译后修饰的影响。了解这些修饰在确定微管功能和性质中所起的作用是一个直到现在才被解决的重大挑战。许多这些修饰同时被发现，导致细胞微管的相当大的多样性，它随着发育、分化、细胞室和细胞周期的不同而不同。我们现在知道，微管蛋白的翻译后修饰不仅影响微管的动力学，还影响微管的组织和与其他细胞成分的相互作用。随着我们对细胞微管多样性的理解，许多关于翻译后修饰如何影响微管的早期建议已经被新的想法甚至新的修饰所取代。
Tubulin and microtubules are subject to a remarkable number of posttranslational modifications. Understanding the roles these modifications play in determining functions and properties of microtubules has presented a major challenge that is only now being met. Many of these modifications are found concurrently, leading to considerable diversity in cellular microtubules, which varies with development, differentiation, cell compartment and cell cycle. We now know that posttranslational modifications of tubulin affect not only the dynamics of the microtubules, but also their organization and interaction with other cellular components. Many early suggestions of how posttranslational modifications affect microtubules have been replaced with new ideas and even new modifications as our understanding of cellular microtubule diversity comes into focus.
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