Strategies for HIV-1 vaccines that induce broadly neutralizing antibodies.
Strategies for HIV-1 vaccines that induce broadly neutralizing antibodies.
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DOI：
10.1038/s41577-022-00753-w
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发表时间：
2023-03
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--
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经过近40年的研究，安全有效的HIV-1疫苗仍然难以捉摸。开发一种有效和持久的HIV-1疫苗具有挑战性的原因有很多，包括HIV-1非凡的遗传多样性及其复杂的免疫逃避机制。HIV-1包膜糖蛋白很少被免疫系统识别，这意味着在HIV-1感染的情况下或通过疫苗接种很少诱导有效的广泛中和抗体（bnAb）。因此，HIV-1-宿主相互作用的生物学需要设计新的疫苗开发策略，以激活和扩增罕见的产生bnAb的B细胞谱系，并选择获得关键的不太可能的bnAb突变。在这里，我们讨论了诱导有效和广泛的HIV-1 bnAb的策略，并概述了最终成功所需的步骤。有许多原因可以解释为什么开发一种有效和持久的HIV-1疫苗是非常具有挑战性的，包括病毒的巨大遗传多样性及其复杂的免疫逃避机制。在这篇综述中，Haynes等人讨论了诱导HIV-1有效的广泛中和抗体的策略以及最终成功所需的步骤。
After nearly four decades of research, a safe and effective HIV-1 vaccine remains elusive. There are many reasons why the development of a potent and durable HIV-1 vaccine is challenging, including the extraordinary genetic diversity of HIV-1 and its complex mechanisms of immune evasion. HIV-1 envelope glycoproteins are poorly recognized by the immune system, which means that potent broadly neutralizing antibodies (bnAbs) are only infrequently induced in the setting of HIV-1 infection or through vaccination. Thus, the biology of HIV-1–host interactions necessitates novel strategies for vaccine development to be designed to activate and expand rare bnAb-producing B cell lineages and to select for the acquisition of critical improbable bnAb mutations. Here we discuss strategies for the induction of potent and broad HIV-1 bnAbs and outline the steps that may be necessary for ultimate success. There are many reasons why the development of a potent and durable vaccine to HIV-1 is exceptionally challenging, including the large genetic diversity of the virus and its complex mechanisms of immune evasion. In this Review, Haynes et al. discuss strategies for the induction of potent broadly neutralizing antibodies for HIV-1 and the steps that may be necessary for ultimate success.
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影响因子：
9.2
作者：
Brouwer PJM;Antanasijevic A;de Gast M;Allen JD;Bijl TPL;Yasmeen A;Ravichandran R;Burger JA;Ozorowski G;Torres JL;LaBranche C;Montefiori DC;Ringe RP;van Gils MJ;Moore JP;Klasse PJ;Crispin M;King NP;Ward AB;Sanders RW
通讯作者：
Sanders RW
影响因子：
32.4
作者：
Alameh MG;Tombácz I;Bettini E;Lederer K;Sittplangkoon C;Wilmore JR;Gaudette BT;Soliman OY;Pine M;Hicks P;Manzoni TB;Knox JJ;Johnson JL;Laczkó D;Muramatsu H;Davis B;Meng W;Rosenfeld AM;Strohmeier S;Lin PJC;Mui BL;Tam YK;Karikó K;Jacquet A;Krammer F;Bates P;Cancro MP;Weissman D;Luning Prak ET;Allman D;Locci M;Pardi N
通讯作者：
Pardi N
影响因子：
3.7
作者：
Akapirat S;Karnasuta C;Vasan S;Rerks-Ngarm S;Pitisuttithum P;Madnote S;Savadsuk H;Rittiroongrad S;Puangkaew J;Phogat S;Tartaglia J;Sinangil F;de Souza MS;Excler JL;Kim JH;Robb ML;Michael NL;Ngauy V;O'Connell RJ;Karasavvas N;RV305 Study Group
通讯作者：
RV305 Study Group
影响因子：
7.8
作者：
Buschmann MD;Carrasco MJ;Alishetty S;Paige M;Alameh MG;Weissman D
通讯作者：
Weissman D
影响因子：
56.9
作者：
BARRESINOUSSI, F;CHERMANN, JC;MONTAGNIER, L
通讯作者：
MONTAGNIER, L