Potential roles of noncoding RNAs in environmental epigenetic transgenerational inheritance.
Potential roles of noncoding RNAs in environmental epigenetic transgenerational inheritance.
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非编码RNA在环境表观遗传转世遗传中的潜在作用。
DOI：
10.1016/j.mce.2014.09.008
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发表时间：
2014-12
影响因子：
4.1
通讯作者：
Yan W
中科院分区：
文献类型：
--
作者：
Yan W
“表观遗传跨代遗传”（ETI）被定义为在没有直接接触或遗传操作的情况下，在代际之间进行表观遗传信息的种系（精子或卵子）传递。在已报告的哺乳动物ETI病例中，大多数是由环境因素引起的，包括环境毒物[如农业杀菌剂vinclozolin、塑料添加剂双酚A、农药甲氧氯、二恶英、邻苯二甲酸二（2-乙基己基）酯、二氯二苯三氯乙烷和碳氢化合物]和营养状况不佳。尽管地外文明现象已经得到了很好的证实，但其背后的机制仍然难以捉摸。据报道，包括DNA甲基化和组蛋白修饰模式的变化在内的推定的表观突变，但尚不清楚这些表观突变最初是如何形成的，以及它们是如何在种系中被记忆并传递给后代的。基于我们对调控非编码rna （regulatory noncoding rna, ncRNAs）的最新了解，我提出ncRNAs参与了ETI，在初始的增殖形成和随后的增殖传递过程中。ncRNAs可以通过影响DNA甲基化和组蛋白修饰在表观遗传水平上发挥作用，从而改变基因转录活性，从而导致与疾病表型相关的mRNA转录组改变。另外，新的或改变的ncRNA表达可导致转录后调控失调，从而直接影响mRNA转录组并诱导疾病表型。精子携带的ncrna是代际表观遗传记忆的潜在介质，但它们单独可能不足以实现代际表观遗传记忆的稳定传递。总的来说，迫切需要对ETI背景下的ncrna进行研究，以揭示ETI的潜在机制。
“Epigenetic Transgenerational Inheritance” (ETI) has been defined as germline (sperm or egg) transmission of epigenetic information between generations in the absence of direct exposures or genetic manipulations. Among reported cases of ETI in mammals, the majority are induced by environmental factors, including environmental toxicants [e.g. agricultural fungicide vinclozolin, plastic additive bisphenol A, pesticide methoxychlor, dioxin, di-(2-ethylhexyl) phthalate, dichlorodiphenyltrichloroethane, and hydrocarbons] and poor nutritional conditions. Although the ETI phenomenon is well established, the underlying mechanism remains elusive. Putative epimutations, including changes in DNA methylation and histone modification patterns, have been reported, but it remains unclear how these epimutations are formed in the first place, and how they are memorized in the germline and then get transmitted to subsequent generations. Based on recent advances in our understanding of regulatory noncoding RNAs (ncRNAs), I propose that ncRNAs are involved in ETI, during both the initial epimutation formation and the subsequent germline transmission of epimutations. ncRNAs can function at epigenetic levels by affecting DNA methylation and histone modifications, thereby changing gene transcriptional activities, which can lead to an altered mRNA transcriptome associated with a disease phenotype. Alternatively, novel or altered ncRNA expression can cause dysregulated post-transcriptional regulation, thus directly affecting the mRNA transcriptome and inducing a disease phenotype. Sperm-borne ncRNAs are potential mediators for epigenetic memory across generations, but they alone may not be sufficient for stable transmission of epimutations across generations. Overall, research on ncRNAs in the context of ETI is urgently needed to shed light on the underlying mechanism of ETI.
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影响因子：
64.8
作者：
通讯作者：
--
影响因子：
3.6
作者：
Doyle, Timothy J.;Bowman, Jennifer L.;Kim, Kwan Hee
通讯作者：
Kim, Kwan Hee
影响因子：
16.8
作者：
Brykczynska, Urszula;Hisano, Mizue;Peters, Antoine H. F. M.
通讯作者：
Peters, Antoine H. F. M.
影响因子：
3.3
作者：
Clement, Tracy M.;Savenkova, Marina I.;Skinner, Michael K.
通讯作者：
Skinner, Michael K.
DOI：
10.1126/science.1191078
发表时间：
2010-10-29
期刊：
Science (New York, N.Y.)
影响因子：
--
作者：
Bonasio R;Tu S;Reinberg D
通讯作者：
Reinberg D