Enamel matrix proteins; old molecules for new applications.
Enamel matrix proteins; old molecules for new applications.
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DOI：
10.1111/j.1601-6343.2009.01459.x
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发表时间：
2009-08
影响因子：
3.1
通讯作者：
Reseland JE
中科院分区：
文献类型：
--
作者：
Lyngstadaas SP;Wohlfahrt JC;Brookes SJ;Paine ML;Snead ML;Reseland JE
Emdogain®（牙釉质基质衍生物，EMD）在牙周病学中得到广泛认可，它被用作牙周手术的局部辅助手段，以刺激因牙周病而丧失的牙周组织的再生。 EMD 的生物学效应是通过刺激治疗组织中的局部生长因子分泌和细胞因子表达，诱导模仿牙本质形成的再生过程。 EMD 的主要 (>95%) 成分是釉原蛋白 (Amel)。迄今为止，尚未从 EMD 中分离出其他活性成分，多项研究表明，纯化的牙釉蛋白可诱导与完整 EMD 相同的效果。牙釉蛋白包含源自一个基因的高度保守的细胞外基质蛋白家族。釉原蛋白的结构和功能在进化过程中得到了很好的保守，这表明它在生物矿化和硬组织形成中发挥着深远的作用。牙釉蛋白的一个特殊特征是，在生理条件下，蛋白质自组装成构成细胞外基质的纳米球。在体内，这种基质在受控过程中被特定的细胞外蛋白水解酶（基质金属蛋白酶）缓慢消化，在施用后数周内向周围组织释放生物活性肽。基于牙周病学的临床和实验观察表明牙釉蛋白对伤口愈合、骨形成和牙根吸收具有显着的积极影响，已经提出了牙釉蛋白的几种新应用。新的实验现在证实牙釉蛋白也有可能用于牙髓学、骨再生、种植学、创伤学和伤口护理领域。
Emdogain® (enamel matrix derivative, EMD) is well recognized in periodontology, where it is used as a local adjunct to periodontal surgery to stimulate regeneration of periodontal tissues lost to periodontal disease. The biological effect of EMD is through stimulation of local growth factor secretion and cytokine expression in the treated tissues, inducing a regenerative process that mimics odontogenesis. The major (>95%) component of EMD is Amelogenins (Amel). No other active components have so far been isolated from EMD, and several studies have shown that purified amelogenins can induce the same effect as the complete EMD. Amelogenins comprise a family of highly conserved extracellular matrix proteins derived from one gene. Amelogenin structure and function is evolutionary well conserved, suggesting a profound role in biomineralization and hard tissue formation. A special feature of amelogenins is that under physiological conditions the proteins self-assembles into nanospheres that constitute an extracellular matrix. In the body, this matrix is slowly digested by specific extracellular proteolytic enzymes (matrix metalloproteinase) in a controlled process, releasing bioactive peptides to the surrounding tissues for weeks after application. Based on clinical and experimental observations in periodontology indicating that amelogenins can have a significant positive influence on wound healing, bone formation and root resorption, several new applications for amelogenins have been suggested. New experiments now confirm that amelogenins have potential for being used also in the fields of endodontics, bone regeneration, implantology, traumatology, and wound care.
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影响因子：
11.4
作者：
LYNGSTADAAS, SP;RISNES, S;PRYDZ, HP
通讯作者：
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影响因子：
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作者：
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