Association of a vascular endothelial growth factor polymorphism with the development of bronchopulmonary dysplasia in Japanese premature newborns.
Association of a vascular endothelial growth factor polymorphism with the development of bronchopulmonary dysplasia in Japanese premature newborns.
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DOI：
10.1038/srep04459
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发表时间：
2014-03-25
影响因子：
4.6
通讯作者：
Morioka I
中科院分区：
文献类型：
--
作者：
Fujioka K;Shibata A;Yokota T;Koda T;Nagasaka M;Yagi M;Takeshima Y;Yamada H;Iijima K;Morioka I
我们的目的是探讨血管内皮生长因子（VEGF）基因多态性与早产儿支气管肺发育不良（BPD）发生风险之间的关系。纳入55例BPD新生儿（BPD：中位胎龄[GA]：27周，出生体重[BW]：786 g）和42例无BPD新生儿（非BPD：中位胎龄[GA]：29周，出生体重：1，165 g），这些新生儿出生时胎龄<32周，并入住科比大学医院。 BPD定义为经后36周时的氧依赖。从脐带、脐带血或颊粘膜中提取基因组DNA。通过DNA测序确定了6种VEGF基因型（-1498T > C、-1154G > A、-634C > G、-7C > T、936 C> T和1612 G> A）。分析BPD组和非BPD组的临床特征、VEGF等位基因和基因型频率。BPD组-634C > G等位基因频率显著高于非BPD组（66.4%vs.50%，P = 0.02）。-634C > G基因型在BPD组和非BPD组之间的分布差异显著（BPD：CC 7%/CG 53%/GG 40%;非BPD：CC 24%/CG 52%/GG 24%; P = 0.04）。多因素Logistic回归分析显示，机械通气时间、VEGF-634 G> C G等位基因、男性是BPD的独立危险因素。结论VEGF-634 C> G多态性可能影响BPD的发病风险。
Our objective was to correlate vascular endothelial growth factor (VEGF) genetic polymorphisms with the risk of bronchopulmonary dysplasia (BPD) development in premature newborns. Fifty-five newborns with BPD (BPD: median gestational age [GA]: 27 weeks, birthweight [BW]: 786 g) and 42 newborns without BPD (non-BPD: median GA: 29 weeks, BW: 1,165 g), who were born at <32 weeks gestational age and were admitted to Kobe University Hospital, were included. BPD was defined as oxygen dependency at 36 weeks postmenstrual age. Genomic DNA was extracted from the umbilical cord, cord blood, or buccal mucosa. Six VEGF genotypes (-1498T > C, -1154G > A, -634C > G, -7C > T, 936C > T, and 1612G > A) were determined by DNA sequencing. Clinical characteristics, and allele and genotype frequencies of VEGF in the BPD and non-BPD groups were analyzed. G allele frequencies in -634C > G of the BPD group were significantly higher than in the non-BPD group (66.4% vs. 50%, P = 0.02). -634C > G genotype distributions differed significantly between the BPD and non-BPD groups (BPD: CC 7%/CG 53%/GG 40%; non-BPD: CC 24%/CG 52%/GG 24%; P = 0.04). Multivariate logistic regression showed that duration of ventilation, VEGF-634G > C G alleles, and male gender were independent risk factors for BPD. In conclusion, polymorphism VEGF -634C > G may influence the risk of BPD.
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DOI：
10.1165/ajrcmb.20.1.3251
发表时间：
1999-01-01
影响因子：
6.4
作者：
Acarregui, MJ;Penisten, ST;Snyder, JM
通讯作者：
Snyder, JM
影响因子：
4.4
作者：
Cooke, RWI;Drury, JA;Clark, D
通讯作者：
Clark, D
影响因子：
3.3
作者：
Fujita, M;Mason, RJ;Fagan, KA
通讯作者：
Fagan, KA
基质金属蛋白酶基因多态性和支气管肺发育不良：将MMP16鉴定为肺发育领域的新参与者。
影响因子：
3.7
作者：
Hadchouel A;Decobert F;Franco-Montoya ML;Halphen I;Jarreau PH;Boucherat O;Martin E;Benachi A;Amselem S;Bourbon J;Danan C;Delacourt C
通讯作者：
Delacourt C
影响因子：
3.6
作者：
Kwinta, Przemko;Bik-Multanowski, Miroslaw;Pietrzyk, Jacek Jozef
通讯作者：
Pietrzyk, Jacek Jozef