A novel nitroxide is an effective brain redox imaging contrast agent and in vivo radioprotector.
A novel nitroxide is an effective brain redox imaging contrast agent and in vivo radioprotector.
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DOI：
10.1016/j.freeradbiomed.2011.05.019
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发表时间：
2011-08-01
影响因子：
7.4
通讯作者：
Mitchell, James B.
中科院分区：
文献类型：
--
作者：
Davis, Ryan M.;Sowers, Anastasia L.;DeGraff, William;Bernardo, Marcelino;Thetford, Angela;Krishna, Murali C.;Mitchell, James B.
关键词：
个人在医疗程序和核灾难期间暴露于电离辐射，这种暴露可能是致癌的，有毒的，有时是致命的。因此，保护个人免受辐射不良影响的药物可能是应对辐照健康风险的宝贵对策。在本研究中，在对照C3 H小鼠和用氮氧化合物辐射保护剂Tempol、3-CP、16 c、22 c和23 c处理的小鼠中测定了LD 50/30（暴露后50%暴露小鼠存活30天的剂量）。用磁共振成像（MRI）测量22 c和23 c在脑、血液、颌下腺、肝脏、肌肉、舌和心肌中的药代动力学。发现23 c是所研究的五种辐射防护剂中最有效的：23 c使小鼠的LD 50/30从7.9 ± 0.15戈伊（用盐水处理）增加到11.47 ± 0.13戈伊（增加45%）。此外，基于MRI的药代动力学研究表明，23 c是小鼠大脑中有效的氧化还原成像剂，并且23 c可以允许心肌的功能成像。本报告中的数据表明，23 c是目前已知的最有效的氮氧化合物辐射防护剂，它也可能用作功能成像的造影剂。
Individuals are exposed to ionizing radiation during medical procedures and nuclear disasters, and this exposure can be carcinogenic, toxic, and sometimes fatal. Drugs that protect individuals from the adverse effects of radiation may therefore be valuable countermeasures against the health risks of exposure. In the current study, the LD50/30 (the dose resulting in 50% of exposed mice surviving 30 days after exposure) was determined in control C3H mice and mice treated with the nitroxide radioprotectors Tempol, 3-CP, 16c, 22c, and 23c. The pharmacokinetics of 22c and 23c were measured with magnetic resonance imaging (MRI) in the brain, blood, submandibular salivary gland, liver, muscle, tongue, and myocardium. It was found 23c was the most effective radioprotector of the five studied: 23c increased the LD50/30 in mice from 7.9 ± 0.15 Gy (treated with saline) to 11.47 ± 0.13 Gy (an increase of 45%). Additionally, MRI-based pharmacokinetic studies revealed that 23c is an effective redox imaging agent in the mouse brain, and that 23c may allow functional imaging of the myocardium. The data in this report suggest that 23c is currently the most potent known nitroxide radioprotector, and that it may also be useful as a contrast agent for functional imaging.
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影响因子：
6.3
作者：
Hyodo, Fuminori;Chuang, Kai-Hsiang;Krishna, Murali C.
通讯作者：
Krishna, Murali C.
DOI：
10.1016/j.saa.2005.10.013
发表时间：
2006-03-13
影响因子：
4.4
作者：
Herrling, T;Jung, K;Fuchs, J
通讯作者：
Fuchs, J
影响因子：
48
作者：
Douw, Linda;Klein, Martin;Heimans, Jan J.
通讯作者：
Heimans, Jan J.
影响因子：
7.3
作者：
Colado, MI;OShea, E;Green, AR
通讯作者：
Green, AR
影响因子：
3.6
作者：
Bobyn, PJ;Franklin, JL;Paterson, PG
通讯作者：
Paterson, PG