COMT moderates the relation of daily maladaptive coping and pain in fibromyalgia.
COMT moderates the relation of daily maladaptive coping and pain in fibromyalgia.
复制标题
DOI：
10.1016/j.pain.2010.10.024
复制
发表时间：
2011-02
期刊：
影响因子：
7.4
通讯作者：
Tennen H
中科院分区：
文献类型：
--
作者：
Finan PH;Zautra AJ;Davis MC;Lemery-Chalfant K;Covault J;Tennen H
45名患有纤维肌痛(FM)的女性接受了为期30天的电子日记评估，记录每天对疼痛的评级和两种形式的适应不良应对方式：疼痛灾难和疼痛注意力。对受试者进行儿茶酚氧位甲基转移酶(COMT)基因val158met单核苷酸多态(Rs4680)的基因分型。COMT基因在不适应应对过程和疼痛的日常关系中起调节作用。与杂合子和纯合子Val158携带者相比，携带MET/MET纯合子基因的FM妇女在疼痛灾害性升高的日子里表现出更多的疼痛。与Val/Val纯合子相比，携带Met/Met纯合子基因的FM女性在疼痛注意力升高的日子里表现出更多的疼痛。有证据表明，这些都是独立的效应。这一发现为适应不良应对和疼痛过程的遗传缓和提供了多措施和多方法支持，这一过程以前曾在手术后肩痛患者的样本中表现出特征。此外，这些发现进一步加深了我们对COMT在FM中的作用的理解，表明val158met多态的遗传变异可能通过与疼痛相关的认知途径影响FM疼痛。
Forty-five women with fibromyalgia (FM) engaged in a 30-day electronic diary assessment, recording daily ratings of pain and two forms of maladaptive coping: pain catastrophizing and pain attention. Participants were genotyped for the val158met single nucleotide polymorphism (rs4680) in the catechol-O-methyltransferase (COMT) gene. COMT genotype moderated the daily relations of both maladaptive coping processes and pain. FM women with the homozygous met/met genotype evidenced more pain on days when pain catastrophizing was elevated relative to heterozygous and homozygous val158 carriers. FM women with the homozygous met/met genotype evidenced more pain on days when pain attention was elevated relative to those with the homozygous val/val genotype. Evidence is presented to suggest that these are independent effects. The findings provide multi-measure and multi-method support for genetic moderation of a maladaptive coping and pain process, which has been previously characterized in a sample of post-operative shoulder pain patients. Further, the findings advance our understanding of the role of COMT in FM, suggesting that genetic variation in the val158met polymorphism may affect FM pain through pathways of pain-related cognition.
登录
查看更多内容
影响因子：
3.5
作者：
Diatchenko, L;Slade, GD;Maixner, W
通讯作者：
Maixner, W
影响因子：
4
作者：
Nezlek, JB
通讯作者：
Nezlek, JB
影响因子：
4.2
作者：
Finan, Patrick H.;Zautra, Alex J.;Davis, Mary C.;Chalfant, Kathryn Lemery;Covault, Jonathan;Tennen, Howard
通讯作者：
Tennen, Howard
影响因子：
7.4
作者：
JENSEN, MP;KAROLY, P;BRAVER, S
通讯作者：
BRAVER, S
影响因子：
4.8
作者：
Ohayon, Maurice M.;Schatzberg, Alan F.
通讯作者：
Schatzberg, Alan F.