Genetic influences on the dynamics of pain and affect in fibromyalgia.
Genetic influences on the dynamics of pain and affect in fibromyalgia.
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DOI：
10.1037/a0018647
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发表时间：
2010-03
影响因子：
4.2
通讯作者：
Tennen, Howard
中科院分区：
文献类型：
--
作者：
Finan, Patrick H.;Zautra, Alex J.;Davis, Mary C.;Chalfant, Kathryn Lemery;Covault, Jonathan;Tennen, Howard
本研究的目的是确定儿茶酚-O-甲基转移酶（COMT）和μ-阿片受体（OPRM 1）基因的变异是否与纤维肌痛（FM）中疼痛相关的正性情感调节相关。46名女性FM患者完成了电子日记，其中包括每天的积极影响和疼痛评估。人与人之间的分析进行了多层次建模。每日积极影响是主要的结果指标。分析显示COMT的显著基因×经验相互作用，例如，与瓦尔/met或瓦尔/瓦尔个体相比，具有met/met基因型的个体在疼痛升高的日子里经历了更大的积极影响下降。这一发现支持的作用，儿茶酚胺在积极的情感反应FM疼痛。OPRM 1的基因×经验相互作用也出现了，表明具有至少一个asp 40等位基因的个体比那些asn 40等位基因纯合子的个体在日常疼痛升高的情况下保持更大的积极影响。这一发现可以用asp 40等位基因在奖赏过程中的作用来解释。总之，这些发现为研究人员提供了充分的理由来进一步研究儿茶酚胺和阿片系统及其相关基因组变体对FM仍然知之甚少的贡献。
The purpose of the present investigation was to determine if variation in the catechol-O-methyltransferase (COMT) and mu-opioid receptor (OPRM1) genes is associated with pain-related positive affective regulation in fibromyalgia (FM). Forty-six female FM patients completed an electronic diary that included daily assessments of positive affect and pain. Between- and within-person analyses were conducted with multilevel modeling. Daily positive affect was the primary outcome measure. Analyses revealed a significant gene × experience interaction for COMT, such that individuals with met/met genotype experienced a greater decline in positive affect on days when pain was elevated than did either val/met or val/val individuals. This finding supports a role for catecholamines in positive affective reactivity to FM pain. A gene × experience interaction for OPRM1 also emerged, indicating that individuals with at least one asp40 allele maintained greater positive affect despite elevations in daily pain than those homozygous for the asn40 allele. This finding may be explained by the asp40 allele’s role in reward processing. Together, the findings offer researchers ample reason to further investigate the contribution of the catecholamine and opioid systems, and their associated genomic variants, to the still poorly understood experience of FM.
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影响因子：
11
作者：
Tiihonen, J;Hallikainen, T;Hietala, J
通讯作者：
Hietala, J
DOI：
10.1073/pnas.96.14.7752
发表时间：
1999-07-06
影响因子：
11.1
作者：
Uhl, GR;Sora, I;Wang, ZJ
通讯作者：
Wang, ZJ
影响因子：
3.5
作者：
Diatchenko, L;Slade, GD;Maixner, W
通讯作者：
Maixner, W
影响因子：
4.9
作者：
Vargas-Alarcón G;Fragoso JM;Cruz-Robles D;Vargas A;Vargas A;Lao-Villadóniga JI;García-Fructuoso F;Ramos-Kuri M;Hernández F;Springall R;Bojalil R;Vallejo M;Martínez-Lavín M
通讯作者：
Martínez-Lavín M
影响因子：
4.7
作者：
Beyer, A;Koch, T;Höllt, V
通讯作者：
Höllt, V