Differences in composition of interdigital skin microbiota predict sheep and feet that develop footrot.
Differences in composition of interdigital skin microbiota predict sheep and feet that develop footrot.
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DOI：
10.1038/s41598-022-12772-7
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发表时间：
2022-05-27
影响因子：
4.6
通讯作者：
Green, Laura E.
中科院分区：
文献类型：
--
作者：
Clifton, Rachel;Monaghan, Emma M.;Green, Martin J.;Purdy, Kevin J.;Green, Laura E.
腐蹄病对全世界绵羊的健康和生产力产生重大影响。当前腐烂病发病机制的范式是指间皮肤（IDS）的物理损伤促进了主要病原体结节二甲杆菌的入侵。健康足部和患病足部的 IDS 微生物群组成不同，因此另一种假设是 IDS 微生物群的变化会促进腐烂足。我们在 20 周内每周研究了 10 只羊的 IDS 微生物群的组成和多样性，其中 5 只确实出现了腐蹄病，另外 5 只则没有（健康）。与健康羊相比，在发生腐蹄病前 2 周以上的绵羊上，IDS 微生物群的多样性较低。这种变化只能用检测到的 2000 个细菌类群中的 7 个来解释。腐烂病的潜伏期为 8-10 天，在潜伏期内发生腐烂病的足部微生物多样性进一步减少。我们得出的结论是，腐蹄病有两个阶段的生态失调：第一个阶段使羊容易发生腐蹄病，第二个阶段发生在腐蹄病潜伏期的足部。这些发现代表了我们对 IDS 微生物群在腐烂病发病机制中的作用的理解的一步改变。
Footrot has a major impact on health and productivity of sheep worldwide. The current paradigm for footrot pathogenesis is that physical damage to the interdigital skin (IDS) facilitates invasion of the essential pathogen Dichelobacter nodosus. The composition of the IDS microbiota is different in healthy and diseased feet, so an alternative hypothesis is that changes in the IDS microbiota facilitate footrot. We investigated the composition and diversity of the IDS microbiota of ten sheep, five that did develop footrot and five that did not (healthy) at weekly intervals for 20 weeks. The IDS microbiota was less diverse on sheep 2 + weeks before they developed footrot than on healthy sheep. This change could be explained by only seven of > 2000 bacterial taxa detected. The incubation period of footrot is 8–10 days, and there was a further reduction in microbial diversity on feet that developed footrot in that incubation period. We conclude that there are two stages of dysbiosis in footrot: the first predisposes sheep to footrot and the second occurs in feet during the incubation of footrot. These findings represent a step change in our understanding of the role of the IDS microbiota in footrot pathogenesis.
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Keystone-Pathogen假设。
DOI：
10.1038/nrmicro2873
发表时间：
2012-10
期刊：
Nature reviews. Microbiology
影响因子：
--
作者：
通讯作者：
--
影响因子：
2.6
作者：
Kaler J;Wani SA;Hussain I;Beg SA;Makhdoomi M;Kabli ZA;Green LE
通讯作者：
Green LE
影响因子：
0.8
作者：
EGERTON, JR;ROBERTS, DS;PARSONSON, IM
通讯作者：
PARSONSON, IM
影响因子：
2.7
作者：
Garcia-Jimenez, Beatriz;Wilkinson, Mark D.
通讯作者：
Wilkinson, Mark D.
影响因子：
8
作者：
Iljazovic A;Roy U;Gálvez EJC;Lesker TR;Zhao B;Gronow A;Amend L;Will SE;Hofmann JD;Pils MC;Schmidt-Hohagen K;Neumann-Schaal M;Strowig T
通讯作者：
Strowig T