A clinical trial comparing parenteral oxytetracyline and enrofloxacin on time to recovery in sheep lame with acute or chronic footrot in Kashmir, India.
A clinical trial comparing parenteral oxytetracyline and enrofloxacin on time to recovery in sheep lame with acute or chronic footrot in Kashmir, India.
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DOI：
10.1186/1746-6148-8-12
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发表时间：
2012-01-31
影响因子：
2.6
通讯作者：
Green LE
中科院分区：
文献类型：
--
作者：
Kaler J;Wani SA;Hussain I;Beg SA;Makhdoomi M;Kabli ZA;Green LE
印度尚未进行关于肠外抗菌药物治疗羊蹄病疗效的临床试验。此外，全球范围内还没有关于肠外抗菌药物治疗慢性腐蹄病疗效的研究。将来自印度克什米尔7个村庄的62只急性蹄病羊和30只慢性蹄病羊招募到两个独立的试验中。采用分层随机抽样将患有急性蹄病的绵羊分配至三种治疗之一：长效肠外土霉素、长效肠外恩诺沙星和局部应用高锰酸钾溶液（印度养羊户使用的传统治疗）。在准干预前后设计中，将对高锰酸钾治疗无反应的慢性蹄病绵羊随机分配至上述两种肠外抗菌剂之一治疗组。在第0天对急性蹄病绵羊进行治疗，在第0、3、6和9天对慢性蹄病绵羊进行治疗。给药后对绵羊进行长达28天的监测。使用Kaplan-Meier生存曲线、非参数对数秩和Wilcoxon符号秩检验评估至跛行恢复和病变初始愈合的时间。有显着的相关性恢复跛行和存在的愈合病变的绵羊急性（r = 0.94）或慢性（r = 0.98）蹄。与局部用高锰酸钾溶液治疗的羊相比，用肠外抗菌剂治疗的急性蹄病羊从跛行中恢复的速度明显更快，并且有愈合的病变（中位数= 7天）（28天内恢复不到50%）。接受任一抗菌剂治疗的慢性蹄病绵羊的中位恢复时间为17天;这显著低于抗菌剂治疗前跛行的中位75天。随着病变严重程度的增加，急性和慢性足炎的中位恢复时间也增加。在急性和慢性受累绵羊中，不同年龄、身体状况评分、跛行持续时间或足部存在脓液的恢复时间无差异。我们的结论是，在印度使用肠外抗菌药物治疗急性或慢性蹄病的羊跛足是非常有效的。这可能会改善农民的福利并给他们带来经济利益。
No clinical trials have been conducted in India on the efficacy of parenteral antibacterials to treat footrot in sheep. In addition, there are no studies worldwide on the efficacy of parenteral antibacterials to treat chronic footrot. Sixty two sheep with acute footrot and 30 sheep with chronic footrot from 7 villages in Kashmir, India were recruited into two separate trials. Sheep with acute footrot were allocated to one of three treatments using stratified random sampling: long acting parenteral oxytetracycline, long acting parenteral enrofloxacin and topical application of potassium permanganate solution (a traditional treatment used by sheep farmers in India). In a quasi pre-post intervention design, sheep with chronic footrot that had not responded to treatment with potassium permanaganate were randomly allocated to treatment with one of the two parenteral antibacterials mentioned above. Sheep with acute footrot were treated on day 0 and those with chronic footrot on days 0, 3, 6 and 9. Sheep were monitored for up to 28 days after treatment. Time to recovery from lameness and initial healing of lesions was assessed using Kaplan-Meier survival curves, nonparametric log-rank and Wilcoxon sign-rank tests. There was significant correlation in recovery from lameness and presence of healing lesions in sheep with acute (r = 0.94) or chronic (r = 0.98) footrot. Sheep with acute footrot which were treated with parenteral antibacterials had a significantly more rapid recovery from lameness and had healing lesions (median = 7 days) compared with those treated with topical potassium permanganate solution (less than 50% recovered in 28 days). The median time to recovery in sheep with chronic footrot treated with either antibacterial was 17 days; this was significantly lower than the median of 75 days lame before treatment with antibacterials. The median time to recovery for both acute and chronic footrot increased as the severity of lesions increased. There was no difference in time to recovery by age, body condition score, duration lame, or presence of pus in the foot within acute and chronically affected sheep. We conclude that use of parenteral antibacterials to treat sheep lame with either acute or chronic footrot in India is highly effective. This is likely to improve welfare and give economic benefits to the farmers.
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影响因子：
--
作者：
Bland, JM;Altman, DG
通讯作者：
Altman, DG
影响因子：
2.6
作者：
Wassink, G. J.;King, E. M.;Green, L. E.
通讯作者：
Green, L. E.
影响因子：
0.8
作者：
EGERTON, JR;ROBERTS, DS
通讯作者：
ROBERTS, DS
影响因子：
2.3
作者：
Rather, M. A.;Wani, S. A.;Magray, S. N.
通讯作者：
Magray, S. N.
影响因子：
1.1
作者：
VENNING, CM;CURTIS, MA;EGERTON, JR
通讯作者：
EGERTON, JR