Distinct beta frequencies reflect categorical decisions.
Distinct beta frequencies reflect categorical decisions.
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DOI：
10.1038/s41467-023-38675-3
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发表时间：
2023-05-22
影响因子：
16.6
通讯作者：
Haegens, Saskia
中科院分区：
文献类型：
--
作者：
Rassi, Elie;Zhang, Yi;Mendoza, German;Mendez, Juan Carlos;Merchant, Hugo;Haegens, Saskia
基于先前在工作记忆和决策中的内容特异性β同步的研究结果，我们假设β振荡通过介导神经系综形成来支持皮层表征的（再）激活。我们发现，在猴子背外侧前额叶皮层（dlPFC）和前辅助运动区（preSMA）的β活动反映了内容的刺激有关的任务背景下，无论其客观属性。在持续时间和距离分类任务中，我们改变了类别之间的边界，从一个试验组到下一个。我们发现，两个不同的β带频率始终与两个相对类别相关，这些带的活动预测了动物的反应。我们在这些频率下将β表征为瞬时爆发，并表明dlPFC和preSMA通过这些不同的频率通道连接。这些结果支持β在形成神经系综中的作用，并进一步表明这些系综在不同的β频率下同步。大脑如何实现依赖于上下文的灵活分类仍然知之甚少。通过观察神经系综的形成，这项研究发现，不同的β节律发出分类决策的信号，并且分类选择神经元在这些频率下同步。
Based on prior findings of content-specific beta synchronization in working memory and decision making, we hypothesized that beta oscillations support the (re-)activation of cortical representations by mediating neural ensemble formation. We found that beta activity in monkey dorsolateral prefrontal cortex (dlPFC) and pre-supplementary motor area (preSMA) reflects the content of a stimulus in relation to the task context, regardless of its objective properties. In duration- and distance-categorization tasks, we changed the boundary between categories from one block of trials to the next. We found that two distinct beta-band frequencies were consistently associated with the two relative categories, with activity in these bands predicting the animals’ responses. We characterized beta at these frequencies as transient bursts, and showed that dlPFC and preSMA are connected via these distinct frequency channels. These results support the role of beta in forming neural ensembles, and further show that such ensembles synchronize at different beta frequencies. How the brain achieves context-dependent, flexible categorization remains poorly understood. By looking at neural ensemble formation, this study finds that distinct beta rhythms signal categorical decisions, and category-selective neurons synchronize at those frequencies.
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