Brain structural connectivity increases concurrent with functional improvement: evidence from diffusion tensor MRI in children with cerebral palsy during therapy.
Brain structural connectivity increases concurrent with functional improvement: evidence from diffusion tensor MRI in children with cerebral palsy during therapy.
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DOI：
10.1016/j.nicl.2015.01.002
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发表时间：
2015
影响因子：
4.2
通讯作者：
Song, Allen W.
中科院分区：
文献类型：
--
作者：
Englander, Zoe A.;Sun, Jessica;Case, Laura;Mikati, Mohamad A.;Kurtzberg, Joanne;Song, Allen W.
脑瘫（CP）是指由发育中的胎儿或婴儿大脑损伤引起的一组永久性但非进行性的运动障碍（Bax等人，2005年）。由于其严重的长期后果，迫切需要有效的干预措施，可以帮助改善运动功能，独立性和生活质量。我们正在进行的治疗CP儿童的纵向临床试验是专门为应对这一挑战而设计的。为了最大限度地提高功能改善的潜力，本试验中的所有儿童都接受了自体脐带血输注（随机顺序，安慰剂给药超过2年），同时接受了更标准的物理和职业治疗。作为这项试验的一部分，磁共振成像（MRI）用于提高我们对这些干预措施如何影响大脑发育的理解，并开发治疗效果的生物标志物。在这份报告中，弥散张量成像（DTI）和随后的脑连接体分析进行了一个子集的儿童参加了临床试验（n = 17），谁都表现出积极的，但不同程度的功能改善，在第一个2年期间的研究。白色物质（WM）连通性的增加和功能改善之间的强相关性被证明;然而，这些因素与儿童入组时的年龄之间没有显着关系。因此，我们的数据表明，大脑连接的增加反映了CP儿童功能能力的改善。在未来的工作中，这种潜在的生物标志物可用于帮助区分功能改善的潜在机制，以及在本研究完成时，在揭盲自体脐带血输注时间后，确定最能促进功能改善的治疗方法。DTI被用来评估与CP儿童的WM连接的变化。连接性的变化与治疗期间功能性能力的变化相关。连通性的变化弥漫分布在整个大脑。脑连接是CP功能改善的潜在生物标志物。
Cerebral Palsy (CP) refers to a heterogeneous group of permanent but non-progressive movement disorders caused by injury to the developing fetal or infant brain (Bax et al., 2005). Because of its serious long-term consequences, effective interventions that can help improve motor function, independence, and quality of life are critically needed. Our ongoing longitudinal clinical trial to treat children with CP is specifically designed to meet this challenge. To maximize the potential for functional improvement, all children in this trial received autologous cord blood transfusions (with order randomized with a placebo administration over 2 years) in conjunction with more standard physical and occupational therapies. As a part of this trial, magnetic resonance imaging (MRI) is used to improve our understanding of how these interventions affect brain development, and to develop biomarkers of treatment efficacy. In this report, diffusion tensor imaging (DTI) and subsequent brain connectome analyses were performed in a subset of children enrolled in the clinical trial (n = 17), who all exhibited positive but varying degrees of functional improvement over the first 2-year period of the study. Strong correlations between increases in white matter (WM) connectivity and functional improvement were demonstrated; however no significant relationships between either of these factors with the age of the child at time of enrollment were identified. Thus, our data indicate that increases in brain connectivity reflect improved functional abilities in children with CP. In future work, this potential biomarker can be used to help differentiate the underlying mechanisms of functional improvement, as well as to identify treatments that can best facilitate functional improvement upon un-blinding of the timing of autologous cord blood transfusions at the completion of this study. DTI was used to assess changes in WM connectivity in children with CP. Changes in connectivity correlate with changes in functional abilities during therapy. Changes in connectivity were diffusely distributed throughout the brain. Brain connectivity is a potential biomarker for functional improvement in CP.
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DOI：
10.1001/archneurpsyc.1942.02290080073002
发表时间：
1942-08-01
影响因子：
--
作者：
Kennard, MA
通讯作者：
Kennard, MA
影响因子：
4.2
作者：
Englander, Zoe A.;Pizoli, Carolyn E.;Batrachenko, Anastasiya;Sun, Jessica;Worley, Gordon;Mikati, Mohamad A.;Kurtzberg, Joanne;Song, Allen W.
通讯作者：
Song, Allen W.
影响因子：
3.3
作者：
Bae, Sang-Hun;Kong, Tae-Ho;Moon, Jisook
通讯作者：
Moon, Jisook
影响因子：
3.7
作者：
Daducci A;Gerhard S;Griffa A;Lemkaddem A;Cammoun L;Gigandet X;Meuli R;Hagmann P;Thiran JP
通讯作者：
Thiran JP
DOI：
10.3233/pnr-14088
发表时间：
2014-06-01
期刊：
JOURNAL OF PEDIATRIC NEURORADIOLOGY
影响因子：
--
作者：
Jain, Krishan K.;Paliwal, Vimal K.;Gupta, Rakesh K.
通讯作者：
Gupta, Rakesh K.