MRI-based Assessment of 3D Intrafractional Motion of Head and Neck Cancer for Radiation Therapy.
MRI-based Assessment of 3D Intrafractional Motion of Head and Neck Cancer for Radiation Therapy.
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基于MRI的头颈癌的3D术内运动评估用于放射治疗。
DOI：
10.1016/j.ijrobp.2017.10.016
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发表时间：
2018-02-01
期刊：
影响因子：
--
通讯作者：
Newbold KL
中科院分区：
文献类型：
--
作者：
Gurney-Champion OJ;McQuaid D;Dunlop A;Wong KH;Welsh LC;Riddell AM;Koh DM;Oelfke U;Leach MO;Nutting CM;Bhide SA;Harrington KJ;Panek R;Newbold KL
确定头颈鳞状细胞癌 (HNSCC) 的 3 维 (3D) 分次内运动。对 56 名 HNSCC 患者治疗位置的动态对比增强磁共振图像进行了分析。动态对比增强磁共振成像由每 2.9 秒采集一次的 3D 图像组成，持续 4 分 50 秒。在初始对比度增强后获得的 3 分 43 秒图像中研究了分次内肿瘤运动。 为了评估肿瘤运动，使用肿瘤周围的感兴趣区域 (ROI) 掩模进行严格配准（仅平移）。将结果与从配准到所有体素的整体身体运动进行比较。运动分为系统运动和随机运动。测试了肿瘤部位和随机运动之间的相关性。受试者内变异系数是通过重复基线测量的 8 名患者确定的。还在放射治疗第一周（38 名患者）和第二周（25 名患者）结束时评估随机运动，以调查运动趋势。在整个治疗过程中，肿瘤表现出不规则的偶尔快速运动（例如吞咽或咳嗽）、周期性中间运动（呼吸）和较慢的系统漂移。 对于 95% 的患者，系统运动和随机运动引起的位移在 95% 的情况下分别 <1.4 毫米和 <2.1 毫米。没有 ROI 掩模的运动显着小于有 ROI 掩模的运动（P<.0001，Wilcoxon 符号秩检验），表明肿瘤可以独立于骨解剖结构移动。下咽部和喉部的肿瘤运动明显大于口咽部的肿瘤运动（P=0.005，Mann-Whitney U 检验）。随机运动的受试者内变异系数为 0.33。在治疗的前两周内，平均随机肿瘤运动没有显着增加。 HNSCC 的 3D 分次内肿瘤运动很小，95% 的时间系统运动 <1.4 mm，随机运动 <2.1 mm。
To determine the 3-dimensional (3D) intrafractional motion of head and neck squamous cell carcinoma (HNSCC). Dynamic contrast-enhanced magnetic resonance images from 56 patients with HNSCC in the treatment position were analyzed. Dynamic contrast-enhanced magnetic resonance imaging consisted of 3D images acquired every 2.9 seconds for 4 minutes 50 seconds. Intrafractional tumor motion was studied in the 3 minutes 43 seconds of images obtained after initial contrast enhancement. To assess tumor motion, rigid registration (translations only) was performed using a region of interest (ROI) mask around the tumor. The results were compared with bulk body motion from registration to all voxels. Motion was split into systematic motion and random motion. Correlations between the tumor site and random motion were tested. The within-subject coefficient of variation was determined from 8 patients with repeated baseline measures. Random motion was also assessed at the end of the first week (38 patients) and second week (25 patients) of radiation therapy to investigate trends of motion. Tumors showed irregular occasional rapid motion (eg, swallowing or coughing), periodic intermediate motion (respiration), and slower systematic drifts throughout treatment. For 95% of the patients, displacements due to systematic and random motion were <1.4 mm and <2.1 mm, respectively, 95% of the time. The motion without an ROI mask was significantly (P<.0001, Wilcoxon signed rank test) less than the motion with an ROI mask, indicating that tumors can move independently from the bony anatomy. Tumor motion was significantly (P=.005, Mann-Whitney U test) larger in the hypopharynx and larynx than in the oropharynx. The within-subject coefficient of variation for random motion was 0.33. The average random tumor motion did not increase notably during the first 2 weeks of treatment. The 3D intrafractional tumor motion of HNSCC is small, with systematic motion <1.4 mm and random motion <2.1 mm 95% of the time.
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影响因子：
6.7
作者：
Freedman JN;Collins DJ;Bainbridge H;Rank CM;Nill S;Kachelrieß M;Oelfke U;Leach MO;Wetscherek A
通讯作者：
Wetscherek A
影响因子：
5.7
作者：
Lens, Eelco;Gurney-Champion, Oliver J.;Bel, Arjan
通讯作者：
Bel, Arjan
DOI：
10.1016/s0360-3016(02)02884-5
发表时间：
2002-08-01
影响因子：
7
作者：
Jaffray, DA;Siewerdsen, JH;Martinez, AA
通讯作者：
Martinez, AA
影响因子：
5.7
作者：
NIEWALD, M;LEHMANN, W;LEETZ, HK
通讯作者：
LEETZ, HK
影响因子：
3.5
作者：
Gurney-Champion, Oliver J.;Dahele, Max;Verbakel, Wilko F. A. R.
通讯作者：
Verbakel, Wilko F. A. R.