A rare case report of recurrent atypical meningioma with multiple metastases treated with anti-PD-1 and anti-VEGF therapy.
A rare case report of recurrent atypical meningioma with multiple metastases treated with anti-PD-1 and anti-VEGF therapy.
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DOI：
10.1186/s12883-022-02919-4
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发表时间：
2022-10-22
期刊：
影响因子：
2.6
通讯作者：
Huang, Long
中科院分区：
文献类型：
--
作者：
Zhao, Jia-Li;Liu, Jing;Fang, Ming;Luo, Chen;Gu, Zhen-Bang;Huang, Long
脑膜瘤是最常见的原发性颅内肿瘤，据报道，所有原发性脑膜瘤中有0.1-1%发展为转移瘤。然而，对于脑膜瘤的多发性转移，目前还没有成熟的治疗策略。一名60岁女性于2018年9月接受右额叶脑膜瘤全肿瘤切除术，2021年10月，患者因咳嗽和呼吸急促入院，诊断为转移性脑膜瘤。计算机断层扫描（CT）显示右胸腔和腹腔内存在大肿块。抗PD-1和抗VEGF治疗2个周期后，症状缓解，肿瘤坏死。随访至2022年6月21日，患者已接受每3周一次的11个周期的治疗，无肿瘤进展。该病例显示抗PD-1和抗VEGF联合治疗刺激外周血免疫细胞杀死转移性脑膜瘤细胞。联合免疫治疗对转移性脑膜瘤是否更有效还需进一步探讨。
Meningioma is the most common type of primary intracranial tumor with 0.1–1% of all primary meningiomas have been reported to develop into metastases. However, there is no proven therapeutic strategy for multiple metastases of meningiomas. A 60-year-old female accepted total tumor resection of a right frontal lobe meningioma in September 2018, In October 2021, the patient was admitted to hospital because of cough and shortness of breath and diagnosed with metastatic meningiomas. The computed tomography (CT) scan revealed the presence of large masses in the right thoracic and abdominal cavity. After two cycles of anti-PD-1 and anti-VEGF treatment, the symptoms were relieved and the tumor was necrotic. Follow up to June 21, 2022, the patient has been given eleven cycles of the treatment every 3 weeks without tumor progression. This case showed combined anti-PD-1 and anti-VEGF treatment stimulates peripheral blood immune cells to kill metastatic meningioma cells. Whether combined immunotherapy is more effective for metastatic meningioma needs further exploration.
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