An autopsy case of progressive supranuclear palsy treated with monoclonal antibody against tau
An autopsy case of progressive supranuclear palsy treated with monoclonal antibody against tau
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tau单克隆抗体治疗进行性核上性麻痹尸检一例
DOI：
10.1111/neup.12890
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发表时间：
2023
期刊：
影响因子：
2.3
通讯作者：
Mochizuki Hideki
中科院分区：
文献类型：
--
作者：
Beck Goichi;Yamashita Rika;Kido Kansuke;Ikenaka Kensuke;Chiba Tomoya;Yonenobu Yuki;Saito Yuko;Morii Eiichi;Hasegawa Masato;Murayama Shigeo;Mochizuki Hideki
我们报告一例进行性核上性麻痹（PSP-理查森综合征）的尸检病例。该患者入组了一项II期试验，并接受了单克隆tau抗体（替拉沃尼单抗，ABBV-8 E12）治疗;在临床试验期间，他死于肝内胆管癌和胃肠道出血。神经病理学检查显示神经元丢失、胶质增生和磷酸化tau蛋白在神经元缠结、簇状星形胶质细胞、卷曲体和丝中广泛沉积，主要发生在下橄榄核、小脑齿状核、黑质、中脑被盖、丘脑底核、苍白球、壳核和中央前回，证实了典型的PSP病理学。还发现磷酸化tau在基底神经节中的贝茨细胞、浦肯野细胞和铅笔纤维中积累。总之，在本病例中没有观察到预期来自靶向tau的免疫疗法的额外变化或病理学改变。
We report an autopsy case of progressive supranuclear palsy (PSP‐Richardson syndrome). The individual had been enrolled in a phase 2 trial and received a monoclonal tau antibody (tilavonemab, ABBV‐8E12); he died of intrahepatic cholangiocarcinoma and gastrointestinal bleeding during the clinical trial. Neuropathological examination demonstrated neuronal loss, gliosis, and widespread deposits of phosphorylated tau in the neurofibrillary tangles, tufted astrocytes, coiled bodies, and threads, which mainly occurred in the inferior olive nucleus, dentate nucleus of the cerebellum, substantia nigra, midbrain tegmentum, subthalamic nuclei, globus pallidus, putamen, and precentral gyrus, confirming typical PSP pathology. Phosphorylated tau was also found to accumulate in Betz cells, Purkinje cells, and pencil fibers in the basal ganglia. In conclusion, no additional changes or pathological modifications, which were expected from immunotherapy targeting tau, were visible in the present case.
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影响因子：
4.8
作者：
Dickson, Dennis W.;Ahmed, Zeshan;Josephs, Keith A.
通讯作者：
Josephs, Keith A.
鉴定氨基末端切割的 tau 片段，以区分进行性核上性麻痹和皮质基底节变性。
DOI：
--
发表时间：
2004
期刊：
Ann Neurol 55
影响因子：
--
作者：
Arai T;Ikeda K;Akiyama H;Nonaka T;Hasegawa M et al.
通讯作者：
Hasegawa M et al.
影响因子：
2
作者：
Lamb R;Rohrer JD;Lees AJ;Morris HR
通讯作者：
Morris HR
影响因子：
7.1
作者：
Decker JM;Krüger L;Sydow A;Zhao S;Frotscher M;Mandelkow E;Mandelkow EM
通讯作者：
Mandelkow EM