The immediate effect of COVID-19 pandemic on children and adolescents with obsessive compulsive disorder.
The immediate effect of COVID-19 pandemic on children and adolescents with obsessive compulsive disorder.
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DOI：
10.1186/s12888-020-02905-5
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发表时间：
2020-10-20
期刊：
影响因子：
4.4
通讯作者：
Thomsen PH
中科院分区：
文献类型：
--
作者：
Nissen JB;Højgaard DRMA;Thomsen PH
强迫症（OCD）是一种痛苦的精神疾病。创伤可能触发或加重强迫症症状。COVID-19大流行引发了一场全球危机，并与成人精神疾病的发病有关。人们对患有强迫症的儿童/青少年知之甚少。本研究旨在研究强迫症儿童/青少年如何应对COVID-19危机。向两组不同的儿童/青少年分发了一份调查表。一组是在专门的强迫症诊所新诊断的临床组。所有儿童/青少年目前都与治疗师或医生有密切接触。另一组是通过丹麦强迫症协会确定的调查小组。这些儿童/青少年中的大多数是多年前被诊断出来的，他们的初级治疗已经完成。对于临床组，患者档案中的数据是可用的。在两组中，但在调查组中最明显的是，参与者经历了他们的强迫症、焦虑和抑郁症状的恶化。强迫症的加重与焦虑、抑郁症状的加重以及回避行为的程度相关。对两组来说，强迫症侵袭性症状预示着病情的显著恶化。较差的基线洞察力显示出预测症状恶化的趋势。这种恶化在发病年龄较早且有注意缺陷多动障碍家族史的儿童中最为明显。据我们所知，这是首批研究COVID-19对强迫症儿童/青少年影响的研究之一。在两个不同的人群中进行了研究，进一步证实了这一发现。该研究指出了强迫症表型的影响，基线洞察表明持续的脆弱性，以及精神疾病的家族史。该研究得到了丹麦数据保护局（1-16-02-147-20）的批准，该机构于2020年4月1日注册。向家长和患者提供口头和书面信息，并获得15岁以上患者和家长的书面同意。
Obsessive compulsive disorder (OCD) is a distressing psychiatric disorder. Traumas may trigger or aggravate OCD symptoms. COVID-19 pandemic has coursed a global crisis and has been associated with onset of psychiatric disorders in adults. Little is known about children/adolescents with OCD. The present study aimed to examine how children/adolescents with OCD react towards COVID-19 crisis. A questionnaire was distributed to two separate groups of children/adolescents. One group was a clinical group newly diagnosed at a specialized OCD clinic. All the children/adolescents had a current close contact to a therapist or doctor. The other group was a survey group identified through the Danish OCD Association. Most of these children/adolescents were diagnosed years ago, and their primary treatment was completed. For the clinical group, data from patient files was available. In both groups, but most pronounced in the survey group, participants experienced a worsening of their OCD, anxiety, and depressive symptoms. The aggravation of OCD correlated with the worsening of anxiety, depressive symptoms, and the extent of avoidance behavior. For both groups, OCD aggressive symptoms predicted a significant worsening. Poor baseline insight showed a trend to predict a symptom worsening. The worsening was most pronounced in children with early age of onset and a family history of attention deficit hyperactivity disorder. To our knowledge, this is one of the first studies examining the effect of COVID-19 in children/adolescents with OCD. The effect was examined in two separate populations strengthening the findings. The study points towards an influence of the OCD phenotype, baseline insight suggesting a continued vulnerability, and a family history of psychiatric disorders. The study is approved by the Danish Data Protection Agency (1–16–02-147-20) registered 1st of April 2020. Oral and written information was given to parents and patients and written consent from patients over 15 years and parents were received.
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