BODIPY-tetrazine derivatives as superbright bioorthogonal turn-on probes.

BODIPY-tetrazine derivatives as superbright bioorthogonal turn-on probes.
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DOI:
10.1002/anie.201301100
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发表时间:
2013-07-01
影响因子:
16.6
通讯作者:
Weissleder, Ralph
Weissleder, Ralph
中科院分区:
化学1区
文献类型:
--
作者:
Carlson, Jonathan C. T.;Meimetis, Labros G.;Hilderbrand, Scott A.;Weissleder, Ralph

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The fastest and the brightest: A new design that intimately connects tetrazine to a BODIPY fluorophore enables exceptionally efficient energy transfer and quenching. Upon reaction of the tetrazine, the brightness of the fluorophore increases more than a thousand-fold, a fluorogenic activation up to two orders of magnitude greater than previously described.
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