Perinatal infection, inflammation, and retinopathy of prematurity.
Perinatal infection, inflammation, and retinopathy of prematurity.
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DOI：
10.1016/j.siny.2011.08.007
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发表时间：
2012-02
影响因子：
3
通讯作者：
Dammann, Olaf
中科院分区：
文献类型：
--
作者：
Lee, Jennifer;Dammann, Olaf
The major known risk factors for retinopathy of prematurity (ROP) are extremely low gestational age, exposure to high levels of oxygen early after birth (phase I) and relatively lower oxygen levels later (phase II). In this review, we summarize recent data suggesting that exposure to perinatal infection/inflammation is associated with an increased risk for ROP. Part of this effect might be due to direct exposure of the developing retina to circulating products of infection and/or inflammation. Another potential mechanism that deserves exploration is that inflammation and/or oxidative stress can modify the known increased risk of oxygen-associated ROP. Taken together, accumulating evidence suggests that prenatal, perinatal, and postnatal systemic inflammation contribute to a ‘pre-phase’, sensitizing the pre-ROP retina for subsequent insults, setting the stage for what are now called phase I and phase II of ROP pathogenesis. Strategies targeting inflammatory responses might help reduce the risk for ROP in extremely low gestational age newborns.
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影响因子：
2.5
作者：
Dammann, Olaf;Brinkhaus, Maria-Jantje;Darnmann, Christiane E. L.
通讯作者：
Darnmann, Christiane E. L.
影响因子：
5.1
作者：
Di Fiore, Juliann M.;Bloom, Jeffrey N.;Martin, Richard J.
通讯作者：
Martin, Richard J.
影响因子：
9.8
作者：
Chen, Jing;Smith, Lois E. H.
通讯作者：
Smith, Lois E. H.
影响因子：
8
作者：
Klinger, Gil;Levy, Itzhak;Reichman, Brian
通讯作者：
Reichman, Brian
DOI：
10.1056/nejmoa0911781
发表时间：
2010-05-27
期刊：
The New England journal of medicine
影响因子：
--
作者：
SUPPORT Study Group of the Eunice Kennedy Shriver NICHD Neonatal Research Network;Carlo WA;Finer NN;Walsh MC;Rich W;Gantz MG;Laptook AR;Yoder BA;Faix RG;Das A;Poole WK;Schibler K;Newman NS;Ambalavanan N;Frantz ID 3rd;Piazza AJ;Sánchez PJ;Morris BH;Laroia N;Phelps DL;Poindexter BB;Cotten CM;Van Meurs KP;Duara S;Narendran V;Sood BG;O'Shea TM;Bell EF;Ehrenkranz RA;Watterberg KL;Higgins RD
通讯作者：
Higgins RD