Is hepatitis C associated with atherosclerotic burden? A systematic review and meta-analysis.
Is hepatitis C associated with atherosclerotic burden? A systematic review and meta-analysis.
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丙型肝炎与动脉粥样硬化负担有关吗？
DOI：
10.1371/journal.pone.0106376
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发表时间：
2014
期刊：
影响因子：
3.7
通讯作者：
Zhao Z
中科院分区：
文献类型：
--
作者：
Huang H;Kang R;Zhao Z
背景与目的越来越多的证据表明丙型肝炎病毒感染与动脉粥样硬化有关。然而，在几项研究中有相反的发现，即动脉粥样硬化负担与丙型肝炎病毒感染无关。因此，我们进行了一项荟萃分析，以澄清与未感染人群相比，丙型肝炎病毒感染是否与动脉粥样硬化有关。方法遵循Meta分析的标准操作指南。结果由两名独立调查人员进行的全面数据库搜索确定了14项符合条件的研究进行分析。综合11项研究的数据，报告颈动脉粥样硬化的未调整优势比(OR)；合并的未调整OR(95%可信区间(CI))为1.65(1.21，2.09)。综合8项研究报告颈动脉粥样硬化的调整OR，合并多因素调整OR(95%CI)为1.76(1.20，2.32)。然而，关于冠状动脉或股动脉粥样硬化的研究数量有限，不足以进行分析。结论我们的荟萃分析表明，与经典危险因素无关，丙型肝炎病毒感染与颈动脉粥样硬化有关。因此，我们建议丙型肝炎病毒感染者接受颈动脉粥样硬化风险方面的咨询。
Background and Aims Increasing evidence demonstrates that hepatitis C virus (HCV) infection is associated with atherosclerosis. However, there are contrasting findings in several studies that the atherosclerotic burden is not associated with HCV infections. Therefore, we performed a meta-analysis to clarify if HCV infection is associated with atherosclerosis compared to non-infected people. Methods Standard guidelines for performance of meta-analysis were followed. Results A thorough database search performed by two independent investigators identified 14 eligible studies for analysis. The data from 11 studies were synthesized to report unadjusted odds ratios (ORs) for carotid atherosclerosis; the pooled unadjusted OR (95% confidence interval (CI)) was 1.65 (1.21, 2.09). By synthesizing the data from 8 studies to report adjusted ORs for carotid atherosclerosis the pooled multi-confounder adjusted OR (95% CI) was 1.76 (1.20, 2.32). However, the numbers of studies on coronary or femoral atherosclerosis were limited and not enough for analysis. Conclusions Our meta-analysis indicats that HCV infection is associated with carotid atherosclerosis independent of classical risk factors. Therefore, we would recommend for HCV infected patients to be counseled on their risk for carotid atherosclerosis.
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DOI：
10.1086/599371
发表时间：
2009-07-15
期刊：
Clinical infectious diseases : an official publication of the Infectious Diseases Society of America
影响因子：
--
作者：
Butt AA;Xiaoqiang W;Budoff M;Leaf D;Kuller LH;Justice AC
通讯作者：
Justice AC
影响因子：
5.3
作者：
Adinolfi, Luigi E.;Restivo, Luciano;Florio, Anna
通讯作者：
Florio, Anna
影响因子：
168.9
作者：
Ishizaka, N;Ishizaka, Y;Yamakado, M
通讯作者：
Yamakado, M
影响因子：
3.3
作者：
Ishizaka, Y;Ishizaka, N;Yamakado, M
通讯作者：
Yamakado, M
影响因子：
3.7
作者：
Louie KS;St Laurent S;Forssen UM;Mundy LM;Pimenta JM
通讯作者：
Pimenta JM