Parasite infection leads to widespread glucocorticoid hormone increases in vertebrate hosts: a meta-analysis.
Parasite infection leads to widespread glucocorticoid hormone increases in vertebrate hosts: a meta-analysis.
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寄生虫感染导致脊椎动物宿主体内糖皮质激素广泛增加：一项荟萃分析。
DOI：
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复制
发表时间：
2020
影响因子：
4.8
通讯作者：
J. Koprivnikar
中科院分区：
文献类型：
--
作者：
K. O'Dwyer;F. Dargent;M. Forbes;J. Koprivnikar
寄生虫和病原体（以下简称寄生虫）通常会挑战生物体，但它们的感染对宿主的生理压力程度仍不清楚。重要的是，脊椎动物激素，糖皮质激素（GC），已被报道增加，减少，或显示没有变化源于感染，挑战寄生虫相关的GC反应的一般性，并激发了重要的调节变量的搜索。我们进行了第一次荟萃分析的脊椎动物GC实验感染寄生虫后的变化，从42项研究中提取146个效应量，涉及32个主机和32个寄生虫物种，以测试感染后GC的一般模式，以及主持人的影响。总体而言，感染增加GC相对于初步或控制水平时，从重复测量研究的单一最大效应大小进行了检查，这表明，脊椎动物宿主的寄生虫一般可以被认为是通过提高GC的生理应激源。当所有的效应量包括沿着与感染后采样时间（TPI）的主持人，寄生虫感染仍然有一个积极的影响主机GC。然而，该效应的强度与TPI并不一致，说明寄生虫分类群之间感染过程中GC变化的时间差异（例如，节肢动物对细菌感染）。检查的其他调节变量不影响GC反应。扩大宿主和寄生虫类群的范围，并在关键的时间窗口采样的研究，将有助于我们了解的变化，在主机的压力反应及其后果的健身脊椎动物宿主和他们的寄生虫。
Parasites and pathogens (hereafter parasites) commonly challenge organisms, but the extent to which their infections are physiologically stressful to hosts remains unclear. Importantly, vertebrate hormones, glucocorticoids (GCs), have been reported to increase, decrease, or show no alterations stemming from infections, challenging the generality of parasite-associated GC responses and motivating a search for important moderator variables. We undertook the first meta-analysis of changes in vertebrate GCs following experimental infection with parasites, extracting 146 effect sizes from 42 studies involving 32 host and 32 parasite species to test for general patterns of GC following infection, as well as the influence of moderators. Overall, infection increased GCs relative to preliminary or control levels when the single largest effect sizes from repeated measures studies were examined, suggesting that parasites of vertebrate hosts can be thought of generally as physiological stressors by elevating GCs. When all effect sizes were included along with the moderator of sampling time post-infection (tPI), parasite infection still had a positive effect on host GCs. However, the strength of that effect did not relate consistently to tPI, illustrating temporal differences in GC changes during the course of infection among parasite taxa (e.g., arthropod versus bacterial infections). Other moderator variables examined did not influence GC responses. Studies broadening the range of host and parasite taxa, and sampling during critical time windows, would aid in our understanding of variation in the host stress response and its consequences for fitness of both vertebrate hosts and their parasites.
DOI：
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发表时间：
2020
期刊：
--
影响因子：
--
作者：
J. Seckl
通讯作者：
J. Seckl
影响因子：
5.8
作者：
Herman JP;McKlveen JM;Ghosal S;Kopp B;Wulsin A;Makinson R;Scheimann J;Myers B
通讯作者：
Myers B