Street rabies virus causes dendritic injury and F-actin depolymerization in the hippocampus.
Street rabies virus causes dendritic injury and F-actin depolymerization in the hippocampus.
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街头狂犬病病毒导致海马树突损伤和 F-肌动蛋白解聚
DOI：
10.1099/vir.0.047480-0
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发表时间：
2013-02
期刊：
影响因子：
--
通讯作者：
Sun L
中科院分区：
文献类型：
--
作者：
Song Y;Hou J;Qiao B;Li Y;Xu Y;Duan M;Guan Z;Zhang M;Sun L
狂犬病是一种中枢神经系统的急性病毒感染，在人类和动物中通常是致命的;然而，其发病机制仍然知之甚少。在这项研究中，树突和树突棘在海马CA 1区的形态学变化进行了研究，在小鼠脑内感染MRV株的街头狂犬病病毒。对感染小鼠脑切片的苏木精和伊红以及荧光染色分析显示，神经元体和神经元突起的形态学变化非常少。然而，我们发现树突棘的数量显著减少。从感染病毒的小鼠（胚胎第16.5天）海马衍生的原代神经元培养物也显示树突棘数量明显减少。此外，树突棘数量的减少与肌动蛋白丝（F-actin）的解聚有关。我们认为，所观察到的结构变化可以部分解释在街头狂犬病病毒感染的实验模型中发现的严重临床疾病。
Rabies is an acute viral infection of the central nervous system and is typically fatal in humans and animals; however, its pathogenesis remains poorly understood. In this study, the morphological changes of dendrites and dendritic spines in the CA1 region of the hippocampus were investigated in mice that were infected intracerebrally with an MRV strain of the street rabies virus. Haematoxylin and eosin and fluorescence staining analysis of brain sections from the infected mice showed very few morphological changes in the neuronal bodies and neuronal processes. However, we found a significant decrease in the number of dendritic spines. Primary neuronal cultures derived from the hippocampus of mice (embryonic day 16.5) that were infected with the virus also showed an obvious decrease in the number of dendritic spines. Furthermore, the decrease in the number of dendritic spines was related to the depolymerization of actin filaments (F-actin). We propose that the observed structural changes can partially explain the severe clinical disease that was found in experimental models of street rabies virus infections.
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影响因子：
25
作者：
Fischer, M;Kaech, S;Matus, A
通讯作者：
Matus, A
DOI：
10.1083/jcb.200212140
发表时间：
2003-05-26
期刊：
The Journal of cell biology
影响因子：
--
作者：
Bloom O;Evergren E;Tomilin N;Kjaerulff O;Löw P;Brodin L;Pieribone VA;Greengard P;Shupliakov O
通讯作者：
Shupliakov O
影响因子：
3.3
作者：
Hotulainen, P;Paunola, E;Lappalainen, P
通讯作者：
Lappalainen, P
影响因子：
4
作者：
Ivanov, Anton;Esclapez, Monique;Ferhat, Lotfi
通讯作者：
Ferhat, Lotfi
影响因子：
5.8
作者：
Gu, Yan-Yan;Zhang, Hong-Yu;Jia, Hong-Ti
通讯作者：
Jia, Hong-Ti