Milk epidermal growth factor and gut protection.
Milk epidermal growth factor and gut protection.
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DOI：
10.1016/j.jpeds.2009.11.018
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发表时间：
2010-02
影响因子：
5.1
通讯作者：
Dvorak, Bohuslav
中科院分区：
文献类型：
--
作者：
Dvorak, Bohuslav
Maternal milk is a complex fluid with multifunctional roles within the developing gastrointestinal tract. Epidermal growth factor (EGF) and heparin-binding EGF-like growth factor (HB-EGF) are members of the family of EGF-related peptides. Biological actions of these growth factors are mediated via interaction with the EGF-receptor (EGF-R). In the early postnatal period, breast milk is the major source of EGF for the developing intestinal mucosa. HB-EGF is also detected in breast milk, but in concentrations 2 to 3 times lower than EGF. Under normal physiological conditions, the intestinal epithelium undergoes a continuing process of cell proliferation, differentiation and maturation. EGF plays an important role in these processes. In pathophysiologic situations, EGF contributes to epithelial protection from injury and post-injury mucosal repair. Necrotizing enterocolitis (NEC) is a devastating disease affecting prematurely born infants. The pathogenesis of NEC is not known and there is no effective treatment for this disease. In an experimental NEC model, oral administration of a physiological dose of EGF significantly reduces the incidence and severity of NEC. HB-EGF provides similar protection against NEC, but only when pharmacological doses are used. Further studies are necessary before EGF can be introduced as an efficient therapeutic approach of intestinal injury.
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影响因子：
5.1
作者：
CAPLAN, MS;HSUEH, W
通讯作者：
HSUEH, W
DOI：
10.2741/chailler
发表时间：
1999-01-15
期刊：
Frontiers in Bioscience
影响因子：
--
作者：
Chailler, Pierre;Menard, Daniel
通讯作者：
Menard, Daniel
影响因子：
2.4
作者：
BARLOW, B;SANTULLI, TV;SCHULLINGER, JN
通讯作者：
SCHULLINGER, JN
DOI：
10.1152/ajpgi.00090.2006
发表时间：
2006-11-01
影响因子：
4.5
作者：
Clark, Jessica A.;Doelle, Sarah M.;Dvorak, Bohuslav
通讯作者：
Dvorak, Bohuslav
影响因子：
56.9
作者：
CARPENTER, G
通讯作者：
CARPENTER, G