TCR cross-reactivity and allorecognition: new insights into the immunogenetics of allorecognition.
TCR cross-reactivity and allorecognition: new insights into the immunogenetics of allorecognition.
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DOI：
10.1007/s00251-011-0590-0
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发表时间：
2012-02
期刊：
影响因子：
3.2
通讯作者：
Claas, F. H. J.
中科院分区：
文献类型：
--
作者：
D'Orsogna, L. J.;Roelen, D. L.;Doxiadis, I. I. N.;Claas, F. H. J.
关键词：
同种异体反应性T细胞是移植排斥反应的核心介质，是移植耐受的有效屏障。以前不清楚在受体胸腺中培养的T细胞如何识别同种异体HLA分子。最近的研究表明，幼稚和记忆性CD 4+和CD 8 + T细胞经常对同种异体HLA分子发生交叉反应，这种同种异体识别表现出精致的肽和HLA特异性，并依赖于T细胞受体的公共和私人特异性。在这篇综述中，我们强调了新的见解获得的免疫遗传学的同种异体识别，特别强调如何病毒感染和疫苗接种可能特异性激活同种异体HLA反应性T细胞。我们还简要讨论了病毒特异性T细胞输注产生GvHD的潜力。在了解同种异体移植排斥反应的分子基础方面取得的进展将有望转化为改善同种异体移植物功能和/或存活，并最终诱导耐受。
Alloreactive T cells are core mediators of graft rejection and are a potent barrier to transplantation tolerance. It was previously unclear how T cells educated in the recipient thymus could recognize allogeneic HLA molecules. Recently it was shown that both naïve and memory CD4+ and CD8+ T cells are frequently cross-reactive against allogeneic HLA molecules and that this allorecognition exhibits exquisite peptide and HLA specificity and is dependent on both public and private specificities of the T cell receptor. In this review we highlight new insights gained into the immunogenetics of allorecognition, with particular emphasis on how viral infection and vaccination may specifically activate allo-HLA reactive T cells. We also briefly discuss the potential for virus-specific T cell infusions to produce GvHD. The progress made in understanding the molecular basis of allograft rejection will hopefully be translated into improved allograft function and/or survival, and eventually tolerance induction.
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