LINEs, SINEs and other retroelements: do birds of a feather flock together?
LINEs, SINEs and other retroelements: do birds of a feather flock together?
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DOI：
10.2741/3991
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发表时间：
2012-01-01
期刊：
影响因子：
--
通讯作者：
Roy-Engel AM
中科院分区：
文献类型：
--
作者：
Roy-Engel AM
可移动元素几乎占人类基因组质量的一半。只有来自非ltr（长末端重复）逆转录转座子家族的逆转录元件，包括LINE-1 （L1）及其非自主伙伴，目前是活跃的并有助于新的插入。虽然这些元素似乎具有相同的基本扩增机制，但不同类型的逆转录因子的活性和成功程度各不相同。例如，alu诱导的突变是大多数记录的由插入逆转录因子引起的人类疾病的原因。以哺乳动物的拷贝数作为指标，一些sin比其他逆转录元件（如逆转录原甚至L1）成功得多，这可能是由于插入后选择和克服细胞控制能力的差异。细胞因素对SINE和LINE积分的影响是不同的，这表明它们的放大机制存在一定的差异。我们关注这组逆转录因子的已知方面，并强调它们的相似性和差异，这可能会显著影响它们的生物学影响。
Mobile elements account for almost half of the mass of the human genome. Only the retroelements from the non-LTR (long terminal repeat) retrotransposon family, which include the LINE-1 (L1) and its non-autonomous partners, are currently active and contributing to new insertions. Although these elements seem to share the same basic amplification mechanism, the activity and success of the different types of retroelements varies. For example, Alu-induced mutagenesis is responsible for the majority of the documented instances of human disease induced by insertion of retroelements. Using copy number in mammals as an indicator, some SINEs have been vastly more successful than other retroelements, such as the retropseudogenes and even L1, likely due to differences in post-insertion selection and ability to overcome cellular controls. SINE and LINE integration can be differentially influenced by cellular factors, indicating some differences between in their amplification mechanisms. We focus on the known aspects of this group of retroelements and highlight their similarities and differences that may significantly influence their biological impact.
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影响因子：
14.9
作者：
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Deininger, P
DOI：
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