Modular Tissue Engineering: Engineering Biological Tissues from the Bottom Up.
Modular Tissue Engineering: Engineering Biological Tissues from the Bottom Up.
复制标题
DOI：
10.1039/b814285h
复制
发表时间：
2009
期刊：
影响因子：
3.4
通讯作者：
Khademhosseini A
中科院分区：
文献类型：
--
作者：
Nichol JW;Khademhosseini A
组织工程创造生物组织，旨在改善患病或受损组织的功能。为了增强工程化组织的功能，需要产生模拟天然器官和组织的复杂结构和复杂性的结构。随着希望创造更复杂的组织，如发达的和功能性的微血管，细胞结合基序和组织特异性形态的特征，组织工程技术开始专注于建立模块化的微组织与重复的功能单元。被称为模块化组织工程的新兴领域专注于制造具有特定微结构特征的组织构建块，并使用这些模块化单元自下而上地设计生物组织。在这篇评论中，我们将研究的承诺和缺点的“自下而上”的方法来创建工程生物组织。具体来说，我们将调查目前的技术控制细胞聚集，增殖和细胞外基质沉积，以及方法来产生形状控制的组织模块。然后，我们将重点介绍用于从模块化微尺度单元创建大尺度工程生物组织的技术。
Tissue engineering creates biological tissues that aim to improve the function of diseased or damaged tissues. To enhance the function of engineered tissues there is a need to generate structures that mimic the intricate architecture and complexity of native organs and tissues. With the desire to create more complex tissues with features such as developed and functional microvasculature, cell binding motifs and tissue specific morphology, tissue engineering techniques are beginning to focus on building modular microtissues with repeated functional units. The emerging field known as modular tissue engineering focuses on fabricating tissue building blocks with specific microarchitectural features and using these modular units to engineer biological tissues from the bottom up. In this review we will examine the promise and shortcomings of “bottom-up” approaches to creating engineered biological tissues. Specifically, we will survey the current techniques for controlling cell aggregation, proliferation and extracellular matrix deposition, as well as approaches to generating shape-controlled tissue modules. We will then highlight techniques utilized to create macroscale engineered biological tissues from modular microscale units.
登录
查看更多内容
影响因子：
4.8
作者：
L'Heureux, N;Pâquet, S;Auger, FA
通讯作者：
Auger, FA
影响因子：
3.8
作者：
Gopalan, SM;Flaim, C;McCulloch, AD
通讯作者：
McCulloch, AD
影响因子：
4.8
作者：
Eschenhagen, T;Fink, C;Elson, EL
通讯作者：
Elson, EL
DOI：
10.1073/pnas.0801866105
发表时间：
2008-07-15
影响因子：
11.1
作者：
Du, Yanan;Lo, Edward;Khademhosseini, Ali
通讯作者：
Khademhosseini, Ali
影响因子：
14
作者：
Fukuda, Junji;Khademhosseini, Ali;Langer, Robert
通讯作者：
Langer, Robert