Smoking, alcohol drinking and esophageal cancer: findings from the JACC Study.
Smoking, alcohol drinking and esophageal cancer: findings from the JACC Study.
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DOI：
10.2188/jea.15.s212
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发表时间：
2005-06
影响因子：
4.7
通讯作者：
JACC Study Group
中科院分区：
文献类型：
--
作者：
Sakata K;Hoshiyama Y;Morioka S;Hashimoto T;Takeshita T;Tamakoshi A;JACC Study Group
背景：该研究利用 1988 年至 1990 年在日本 45 个地区建立的约 110,000 人的大规模队列，试图揭示吸烟和饮酒相结合对食道癌死亡率的联合影响。方法：从 1988 年到 1990 年建立的队列包括 40 岁及以上和 80 岁以下的 46,465 名男性和 64,327 名女性。女性吸烟者和饮酒者的数量很少，因此女性被排除在分析之外。此外，还排除了308名有恶性肿瘤病史的人以及3579名吸烟和饮酒数据不清楚的人，总共有42578人可供分析。对这些人的随访一直持续到 1999 年。使用 Cox 比例风险模型进行分析。结果：将每天吸烟数量和饮酒量的联合效应与不吸烟者和不饮酒者或每天饮酒量少于一单位的人进行比较。每天吸烟 20 支或以下、每天饮酒 1 单位或以上但少于 3 单位酒精的人，吸烟和饮酒的协同食管癌死亡率风险增加 (3.88)，而每天吸烟至少 21 支香烟和至少饮用 3 单位酒精的人，其风险上升 (6.30)。即使在饮酒量增加的不吸烟者中，以及在不饮酒者或每天最多饮酒一杯且吸烟量增加的人中，也没有观察到风险增加。结论：在这项针对日本人群的队列研究中，只有当酒精和烟草摄入这两个因素同时存在时，才会观察到食道癌死亡风险增加。
BACKGROUND: Using a large-scale cohort of about 110,000 people established in 45 areas throughout Japan from 1988 through 1990, the study attempted to uncover the joint effects of combined smoking and alcohol intake on esophageal cancer mortality. METHODS: A cohort established from 1988 through 1990 included 46,465 men and 64,327 women aged 40 years and older and younger than 80. The number of female smokers and drinkers was low, and women were excluded from the analysis for that reason. In addition, 308 people with histories of malignant neoplasm, and 3,579 with unclear smoking and drinking data were also excluded, resulting in 42,578 people available for analysis. A follow-up of these individuals was conducted until 1999. Cox proportional hazards model was used for the analysis. RESULTS: The joint effects of number of cigarettes and amount of alcohol consumed per day were compared with non-smokers and non-drinkers or those consuming less than one unit of alcohol per day. An increased synergistic esophageal cancer mortality risk (3.88) for both smoking and drinking was observed for those smoking 20 cigarettes or less per day and drinking one unit of alcohol or more but less than three units per day, with the risk rising (6.30) for those smoking at least 21 cigarettes and drinking at least three units of alcohol per day. Even in non-smokers with increased alcohol consumption, and in non-drinkers or those drinking at most one drink per day with increased smoking, no increased risk was observed. CONCLUSIONS: In this cohort study of a Japanese population, increased esophageal cancer mortality risk was observed only when both factors of alcohol and tobacco intake were present simultaneously.
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影响因子：
10.4
作者：
Akiba S
通讯作者：
Akiba S
影响因子：
6.3
作者：
NAKACHI, K;IMAI, K;SASABA, T
通讯作者：
SASABA, T
影响因子：
8.8
作者：
Launoy G;Milan CH;Faivre J;Pienkowski P;Milan CI;Gignoux M
通讯作者：
Gignoux M
影响因子：
6.4
作者：
Znaor, A;Brennan, P;Boffeta, P
通讯作者：
Boffeta, P
影响因子：
6.2
作者：
YOKOYAMA, A;OHMORI, T;ISHII, H
通讯作者：
ISHII, H