The role of the placenta in iron transfer from mother to fetus and the relationship between iron status and fetal outcome
The role of the placenta in iron transfer from mother to fetus and the relationship between iron status and fetal outcome
复制标题
胎盘在铁从母体转移到胎儿中的作用以及铁状态与胎儿结局之间的关系
作者：
H. Mcardle;R. Danzeisen;C. Fosset;L. Gambling
在怀孕期间，铁通过胎盘从母亲转移到胎儿。其机理已被广泛研究。铁代谢的改变改变了铁的转移，但也有其他后果。在这篇综述中，我们研究了胎盘如何适应铁供应的改变，无论是在细胞因子表达的变化和铁转移的蛋白质。改变铁水平会改变其他金属的水平，特别是铜，我们回顾这是如何与改变功能。对胎盘本身、血管形成和生理的其他方面也有影响。反过来，这对胎儿有影响，我们回顾一下生长和发育是如何改变的。最后，我们研究更详细的外排过程中，它是如何调节，特别是胎盘铜氧化酶在外排过程中的假定作用。在适当的情况下，我们利用来自人类、动物模型和细胞培养系统的数据来说明这些信息。
During pregnancy, iron is transferred from the mother to the fetus across the placenta. The mechanism has been extensively studied. Altered iron metabolism changes transfer, but also has other consequences. In this review, we examine how the placenta adapts to altered iron supply, both in terms of changing cytokine expression and in relation to the proteins of iron transfer. Changing iron levels alters the levels of other metals, especially copper, and we review how this is related to changing function. There are also consequences to the placenta itself, to vascularisation and other aspects of the physiology. In turn, this has effects on the fetus and we review how growth and development are modified. Finally, we examine in more detail the efflux process, how it is regulated and, especially, the putative role of the placental Cu oxidase in the efflux process. As appropriate, we draw on data from humans, from animal models and from cell culture systems to illustrate the information.
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影响因子：
7.1
作者：
SCHOLL, TO;HEDIGER, ML;SHEARER, JW
通讯作者：
SHEARER, JW
影响因子：
4.2
作者：
Kwik-Uribe, CL;Gietzen, D;Keen, CL
通讯作者：
Keen, CL
DOI：
10.1073/pnas.92.7.2539
发表时间：
1995-03-28
影响因子：
11.1
作者：
HARRIS, ZL;TAKAHASHI, Y;GITLIN, JD
通讯作者：
GITLIN, JD
影响因子：
56.9
作者：
Mukhopadhyay, CK;Attieh, ZK;Fox, PL
通讯作者：
Fox, PL
铜蓝蛋白基因无义突变导致糖尿病和神经退行性疾病的特征。
影响因子：
3.5
作者：
Takahashi,Y;Miyajima,H;Shirabe,S;Nagataki,S;Suenaga,A;Gitlin,JD
通讯作者：
Gitlin,JD