Injectable citrate-based mussel-inspired tissue bioadhesives with high wet strength for sutureless wound closure.
Injectable citrate-based mussel-inspired tissue bioadhesives with high wet strength for sutureless wound closure.
复制标题
DOI：
10.1016/j.biomaterials.2012.07.055
复制
发表时间：
2012-11
期刊：
影响因子：
14
通讯作者：
Yang, Jian
中科院分区：
文献类型：
--
作者：
Mehdizadeh, Mohammadreza;Weng, Hong;Gyawali, Dipendra;Tang, Liping;Yang, Jian
The existing surgical adhesives are not ideal for wet tissue adhesion required in many surgeries such as those for internal organs. Developing surgical adhesives with strong wet tissue adhesion, controlled degradability and mechanical properties, and excellent biocompatibility has been a significant challenge. Herein, learning from nature, we report a one-step synthesis of a family of injectable citrate-based mussel-inspired bioadhesives (iCMBAs) for surgical use. Within the formulations investigated, iCMBAs showed 2.5–8.0 folds stronger wet tissue adhesion strength over the clinically used fibrin glue, demonstrated controlled degradability and tissue-like elastomeric mechanical properties, and exhibited excellent cyto/tissue-compatibility both in vitro and in vivo. iCMBAs were able to stop bleeding instantly and suturelessly, and close wounds (2 cm long × 0.5 cm deep) created on the back of Sprague-Dawley rats, which is impossible when using existing gold standard, fibrin glue, due to its weak wet tissue adhesion strength. Equally important, the new bioadhesives facilitate wound healing, and are completely degraded and absorbed without eliciting significant inflammatory response. Our results support that iCMBA technology is highly translational and could have broad impact on surgeries where surgical tissue adhesives, sealants, and hemostatic agents are used.
登录
查看更多内容
影响因子：
14
作者：
Brubaker, Carrie E.;Kissler, Hermann;Wang, Ling-Jia;Kaufman, Dixon B.;Messersmith, Phillip B.
通讯作者：
Messersmith, Phillip B.
影响因子：
14
作者：
Gyawali, Dipendra;Nair, Parvathi;Yang, Jian
通讯作者：
Yang, Jian
影响因子：
2.2
作者：
JORGENSEN, PH;JENSEN, KH;ANDREASSEN, TT
通讯作者：
ANDREASSEN, TT
影响因子：
3
作者：
Barroso-Bujans, F;Martínez, R;Ortiz, P
通讯作者：
Ortiz, P
影响因子：
56.9
作者：
Lee, Haeshin;Dellatore, Shara M.;Messersmith, Phillip B.
通讯作者：
Messersmith, Phillip B.