High TSTA3 Expression as a Candidate Biomarker for Poor Prognosis of Patients With ESCC.
High TSTA3 Expression as a Candidate Biomarker for Poor Prognosis of Patients With ESCC.
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TSTA3 高表达作为 ESCC 患者预后不良的候选生物标志物。
DOI：
10.1177/1533033818781405
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发表时间：
2018-01-01
影响因子：
2.8
通讯作者：
Cui Y
中科院分区：
文献类型：
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作者：
Yang J;Kong P;Yang J;Jia Z;Hu X;Wang Z;Cui H;Bi Y;Qian Y;Li H;Wang F;Yang B;Yan T;Ma Y;Zhang L;Cheng C;Song B;Li Y;Xu E;Liu H;Gao W;Wang J;Liu Y;Zhai Y;Chang L;Wang Y;Zhang Y;Shi R;Liu J;Wang Q;Cheng X;Cui Y
食管鳞状细胞癌是全球第六大致死性癌症，在中国是第四大致死性癌症。组织特异性移植抗原P35 B编码参与GDP-1-岩藻糖生物合成的酶GDP-d-甘露糖-4，6-脱氢酶。GDP-1-岩藻糖是参与许多糖蛋白的生物合成的重要底物。癌细胞往往伴随着糖蛋白结构的改变，从而影响细胞的粘附、侵袭和转移。组织特异性移植抗原P35 B是否对食管鳞癌的发生发展有影响尚不清楚。我们采用免疫组化方法检测了104例食管鳞癌组织中组织特异性移植抗原P35 B的表达。结果显示，组织特异性移植抗原P35 B表达与患者的一些临床特征相关，如年龄（P = .017），临床分期（P = .010）和淋巴结转移（P = .043）。Kaplan-Meier分析和log-rank检验显示组织特异性移植抗原P35 B高表达的食管鳞癌患者的预后比低表达的患者差（P = 0.048）。多因素考克斯比例风险回归模型显示，组织特异性移植抗原P35 B高表达可独立预测食管鳞癌患者的不良预后。结论：岩藻糖基化异常可能参与了食管鳞癌的发生、发展过程，组织特异性移植抗原P35 B可作为食管鳞癌患者预后的一种新的生物标志物。
Esophageal squamous cell carcinoma is the sixth most lethal cancer worldwide and the fourth most lethal cancer in China. Tissue-specific transplantation antigen P35B codifies the enzyme GDP-d-mannose-4,6-dehydratase, which participates in the biosynthesis of GDP-l-fucose. GDP-l-fucose is an important substrate involved in the biosynthesis of many glycoproteins. Cancer cells are often accompanied by the changes in glycoprotein structure, which affects the adhesion, invasion, and metastasis of cells. It is not clear whether tissue-specific transplantation antigen P35B has any effect on the development of esophageal squamous cell carcinoma. We used an immunohistochemical method to assess the expression of tissue-specific transplantation antigen P35B in 104 esophageal squamous cell carcinoma samples. The results showed tissue-specific transplantation antigen P35B expression was associated with some clinical features in patients, such as age (P = .017), clinical stage (P = .010), and lymph node metastasis (P = .043). Kaplan-Meier analysis and log-rank test showed that patients with esophageal squamous cell carcinoma having high tissue-specific transplantation antigen P35B expression had a worse prognosis compared to the patients with low expression (P = .048). Multivariate Cox proportional hazards regression model showed that high expression of tissue-specific transplantation antigen P35B could predict poor prognosis for patients with esophageal squamous cell carcinoma independently. In conclusion, abnormal fucosylation might participate in the progress of esophageal squamous cell carcinoma and tissue-specific transplantation antigen P35B may serve as a novel biomarker for prognosis of patients with esophageal squamous cell carcinoma.
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基因组分析表明 FAM84B 和 NOTCH 通路与食管鳞状细胞癌的进展相关。
影响因子：
9.2
作者：
Cheng C;Cui H;Zhang L;Jia Z;Song B;Wang F;Li Y;Liu J;Kong P;Shi R;Bi Y;Yang B;Wang J;Zhao Z;Zhang Y;Hu X;Yang J;He C;Zhao Z;Wang J;Xi Y;Xu E;Li G;Guo S;Chen Y;Yang X;Chen X;Liang J;Guo J;Cheng X;Wang C;Zhan Q;Cui Y
通讯作者：
Cui Y
DOI：
10.1158/1078-0432.ccr-09-0536
发表时间：
2009-11-01
期刊：
Clinical cancer research : an official journal of the American Association for Cancer Research
影响因子：
--
作者：
Herbertson RA;Tebbutt NC;Lee FT;MacFarlane DJ;Chappell B;Micallef N;Lee ST;Saunder T;Hopkins W;Smyth FE;Wyld DK;Bellen J;Sonnichsen DS;Brechbiel MW;Murone C;Scott AM
通讯作者：
Scott AM
胰腺癌中的糖蛋白和糖蛋白质组学。
影响因子：
4.3
作者：
Pan S;Brentnall TA;Chen R
通讯作者：
Chen R
影响因子：
3.2
作者：
Burvenich IJ;Lee FT;O'Keefe GJ;Makris D;Cao D;Gong S;Rigopoulos A;Allan LC;Brechbiel MW;Liu Z;Ramsland PA;Scott AM
通讯作者：
Scott AM
影响因子：
2.8
作者：
Niittymaki, Jaana;Mattila, Pirkko;Renkonen, Risto
通讯作者：
Renkonen, Risto