Carbohydrate vaccines: developing sweet solutions to sticky situations?

Carbohydrate vaccines: developing sweet solutions to sticky situations?
复制标题

碳水化合物疫苗:为粘性情况开发甜蜜的解决方案吗?

DOI:
10.1038/nrd3012
复制
发表时间:
2010-04
期刊:
Nature reviews. Drug discovery
影响因子:
--
通讯作者:
--
中科院分区:
其他
文献类型:
--
作者:

文献摘要

参考文献

被引文献

相似文献

碳水化合物疫苗的领域已经远远超出了细菌病原体的荚膜多糖,包括几乎代表每一个生物王国的各种目标集合。糖生物学和糖化学方面的最新技术进步为碳水化合物疫苗设计的新时代铺平了道路,使鉴定、合成和评估在大量病原体和恶性细胞上发现的独特糖基表位的效率更高。本文综述了针对细菌、原生动物、蠕虫、病毒、真菌和癌症的表面碳水化合物作为疫苗的研究进展。
The realm of carbohydrate vaccines has expanded far beyond the capsular polysaccharides of bacterial pathogens to include a diverse collection of targets representing nearly every biological kingdom. Recent technological advances in glycobiology and glycochemistry are paving the way for a new era in carbohydrate vaccine design enabling greater efficiency in the identification, synthesis and evaluation of unique glycan epitopes found on a plethora of pathogens and malignant cells. This article reviews the progress being made in addressing challenges posed by targeting the surface carbohydrates of bacteria, protozoa, helminths, viruses, fungi and cancer for vaccine purposes.
DOI: 10.1086/499821
发表时间: 2006-02-15
影响因子: 6.4
作者:
Ahmed, A;Li, JP;Szu, SC
通讯作者: Szu, SC
DOI: 10.1002/chem.200400074
发表时间: 2004-07-19
影响因子: 4.3
作者:
Buskas, T;Li, YH;Boons, GJ
通讯作者: Boons, GJ
DOI: 10.1016/j.cell.2004.05.001
发表时间: 2004-05-28
期刊: CELL
影响因子: 64.5
作者:
Cobb, BA;Wang, O;Kasper, DL
通讯作者: Kasper, DL
DOI: 10.1016/j.amjsurg.2005.06.013
发表时间: 2005-10-01
影响因子: 3
作者:
Braun, DP;Crist, KA;Parker, J
通讯作者: Parker, J
DOI: 10.1351/pac199365040763
发表时间: 1993-04-01
影响因子: 1.8
作者:
CARVER, JP
通讯作者: CARVER, JP