Longitudinal associations of DNA methylation and sleep in children: a meta-analysis.
Longitudinal associations of DNA methylation and sleep in children: a meta-analysis.
复制标题
DOI：
10.1186/s13148-022-01298-4
复制
发表时间：
2022-07-05
影响因子：
5.7
通讯作者：
中科院分区：
文献类型：
--
作者：
睡眠对儿童的健康功能很重要。许多遗传和环境因素，从概念开始，可能会影响这种表型。DNA甲基化等表观遗传机制被认为是睡眠变化的基础，或者可能是睡眠障碍的早期标志。我们研究了出生时或学龄期的DNA甲基化是否与父母报告的儿童睡眠结果和活动记录估计的儿童睡眠结果相关。我们荟萃分析了表观基因组关联研究结果。在11个队列中从出生时的脐带血和8个队列中从儿童（4-13岁）的外周血测量DNA甲基化。结果包括父母报告的睡眠持续时间，睡眠开始和碎片问题，和活动记录估计的睡眠持续时间，睡眠开始潜伏期和觉醒后的睡眠开始持续时间。我们发现，出生时DNA甲基化与父母报告的睡眠时间（n = 3658）、启动问题（n = 2504）或片段化（n = 1681）之间没有关联（p值高于临界值4.0 × 10-8）。出生时cg 24815001和cg 02753354的甲基化水平较低，分别与较长的活动记录估计的睡眠时间（p = 3.31 × 10-8，n = 577）和睡眠起始潜伏期（p = 8.8 × 10-9，n = 580）相关。儿童期DNA甲基化与任何睡眠结果均无横断面相关性（n = 716-2539）。出生时或儿童期的DNA甲基化与父母报告的睡眠无关。如果有更多的数据集可用，可以进一步研究观察到的与客观测量的睡眠结果的关联。在线版本包含补充材料，可通过10.1186/s13148-022-01298-4获得。
Sleep is important for healthy functioning in children. Numerous genetic and environmental factors, from conception onwards, may influence this phenotype. Epigenetic mechanisms such as DNA methylation have been proposed to underlie variation in sleep or may be an early-life marker of sleep disturbances. We examined if DNA methylation at birth or in school age is associated with parent-reported and actigraphy-estimated sleep outcomes in children. We meta-analysed epigenome-wide association study results. DNA methylation was measured from cord blood at birth in 11 cohorts and from peripheral blood in children (4–13 years) in 8 cohorts. Outcomes included parent-reported sleep duration, sleep initiation and fragmentation problems, and actigraphy-estimated sleep duration, sleep onset latency and wake-after-sleep-onset duration. We found no associations between DNA methylation at birth and parent-reported sleep duration (n = 3658), initiation problems (n = 2504), or fragmentation (n = 1681) (p values above cut-off 4.0 × 10–8). Lower methylation at cg24815001 and cg02753354 at birth was associated with longer actigraphy-estimated sleep duration (p = 3.31 × 10–8, n = 577) and sleep onset latency (p = 8.8 × 10–9, n = 580), respectively. DNA methylation in childhood was not cross-sectionally associated with any sleep outcomes (n = 716–2539). DNA methylation, at birth or in childhood, was not associated with parent-reported sleep. Associations observed with objectively measured sleep outcomes could be studied further if additional data sets become available. The online version contains supplementary material available at 10.1186/s13148-022-01298-4.
登录
查看更多内容
影响因子：
4
作者：
Amado-Azevedo, J.;Reinhard, N. R.;Hordijk, P. L.
通讯作者：
Hordijk, P. L.
影响因子：
9.8
作者：
Joubert, Bonnie R.;Felix, Janine F.;London, Stephanie J.
通讯作者：
London, Stephanie J.
影响因子：
3
作者：
Mägi R;Morris AP
通讯作者：
Morris AP
影响因子：
3.5
作者：
Gaine ME;Chatterjee S;Abel T
通讯作者：
Abel T
DOI：
10.1111/j.2517-6161.1995.tb02031.x
发表时间：
1995-01-01
影响因子：
5.8
作者：
BENJAMINI, Y;HOCHBERG, Y
通讯作者：
HOCHBERG, Y