Thymic stromal lymphopoietin controls hair growth.
Thymic stromal lymphopoietin controls hair growth.
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胸腺基质淋巴细胞生成素控制毛发生长。
DOI：
10.1016/j.stemcr.2022.01.017
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发表时间：
2022-03-08
影响因子：
5.9
通讯作者：
Zhang, Jennifer Y.
中科院分区：
文献类型：
--
作者：
Shannon, Jessica L.;Corcoran, David L.;Murray, John C.;Ziegler, Steven F.;MacLeod, Amanda S.;Zhang, Jennifer Y.
损伤后的皮肤组织再生涉及毛囊中干细胞（HFSC）信号的产生和整合。关于特定的伤口衍生因子如何调节干细胞对毛发生长的贡献，仍有很多未知之处。我们证明，胸腺基质淋巴细胞生成素（TSLP）是在响应皮肤损伤和毛发生长周期的生长期。皮内注射TSLP促进创伤诱导毛发生长（WIHG），而中和TSLP受体（TSLPR）抑制WIHG。流式细胞术和荧光免疫染色显示TSLP促进了trans-amplification细胞的增殖。HFSC中Lgr 5CreER介导的Tslpr缺失抑制创伤诱导的和外源性TSLP诱导的毛发生长。我们的数据突出了TSLP在体内平衡和伤口愈合过程中调节毛囊活性的新功能。TSLP在皮肤中产生，以响应损伤和毛囊周期。毛囊中的LGR 5+干细胞和后代对TSLP有反应。LGR 5 + HFSC上Tslpr的靶向缺失延迟了伤口诱导的毛发生长。TSLP介导细胞周期蛋白D1和DDX 6上调并驱动角质形成细胞增殖。Zhang及其同事表明，胸腺基质淋巴细胞生成素是在皮肤损伤和毛囊循环过程中产生的。重组TSLP通过促进过渡扩增细胞的增殖作用于LGR 5+毛囊干细胞，足以诱导小鼠毛发生长。
Skin tissue regeneration after injury involves the production and integration of signals by stem cells residing in hair follicles (HFSCs). Much remains unknown about how specific wound-derived factors modulate stem cell contribution to hair growth. We demonstrate that thymic stromal lymphopoietin (TSLP) is produced in response to skin injury and during the anagen phase of the hair cycle. Intradermal injection of TSLP promoted wound-induced hair growth (WIHG), whereas neutralizing TSLP receptor (TSLPR) inhibited WIHG. Using flow cytometry and fluorescent immunostaining, we found that TSLP promoted proliferation of transit-amplifying cells. Lgr5CreER-mediated deletion of Tslpr in HFSCs inhibited both wound-induced and exogenous TSLP-induced hair growth. Our data highlight a novel function for TSLP in regulation of hair follicle activity during homeostasis and wound healing. TSLP is produced in the skin in response to injury and during hair follicle cycling. LGR5+ stem cells and progeny in the hair follicle respond to TSLP. Targeted deletion of Tslpr on LGR5+ HFSCs delays wound-induced hair growth. TSLP mediates cyclin D1 and DDX6 upregulation and drives keratinocyte proliferation. Zhang and colleagues show that thymic stromal lymphopoietin is produced in response to skin injury and during hair follicle cycling. Recombinant TSLP was sufficient to induce hair growth in mice by acting on LGR5+ hair follicle stem cells by promoting proliferation of transit-amplifying cells.
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DOI：
10.1084/jem.20062211
发表时间：
2007-02-19
期刊：
The Journal of experimental medicine
影响因子：
--
作者：
Allakhverdi Z;Comeau MR;Jessup HK;Yoon BR;Brewer A;Chartier S;Paquette N;Ziegler SF;Sarfati M;Delespesse G
通讯作者：
Delespesse G
DOI：
10.1126/science.abd2893
发表时间：
2021-07-30
期刊：
Science (New York, N.Y.)
影响因子：
--
作者：
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通讯作者：
Kambayashi T
DOI：
10.1126/science.1242281
发表时间：
2014-06-13
期刊：
Science (New York, N.Y.)
影响因子：
--
作者：
Blanpain C;Fuchs E
通讯作者：
Fuchs E
DOI：
10.1073/pnas.0801532105
发表时间：
2008-08-19
影响因子：
11.1
作者：
He, Rui;Oyoshi, Michiko K.;Geha, Raif S.
通讯作者：
Geha, Raif S.
影响因子：
64.5
作者：
Hsu YC;Li L;Fuchs E
通讯作者：
Fuchs E