Protective and pathologic immune responses in human tegumentary leishmaniasis.
Protective and pathologic immune responses in human tegumentary leishmaniasis.
复制标题
DOI：
10.3389/fimmu.2012.00301
复制
发表时间：
2012
影响因子：
7.3
通讯作者：
Carvalho EM
中科院分区：
文献类型：
--
作者：
Carvalho LP;Passos S;Schriefer A;Carvalho EM
近年来的研究使人们对宿主和寄生虫因素在人体表皮利什曼病发病机制中的作用有了新的认识。来自同一物种的利什曼原虫种群内的多态性已被记录;表明不同菌株的感染可能导致不同的临床表现，也可能干扰对治疗的反应。此外，检测寄生虫基因标签以精确识别菌株将改善针对利什曼病的诊断和治疗。在宿主方面，虽然占优势的Th 1型免疫应答对于控制寄生虫生长是重要的，但它不能根除利什曼原虫，并且在某些情况下，不能防止寄生虫传播。越来越多的证据表明，CD 4+和CD 8 + T细胞以及巨噬细胞参与了与L. braziliensis、巴西湖蝇L. guayanensis和L.严重感染大部分感染利什曼原虫的个体不会发生疾病的发现将有助于了解宿主如何控制利什曼原虫感染。由于这些人比皮肤利什曼病患者的1型免疫反应更弱，因此这些人的寄生虫复制控制可能主要依赖于先天免疫，应强调中性粒细胞，巨噬细胞和NK细胞杀死利什曼原虫的能力。
Studies in the recent years have advanced the knowledge of how host and parasite factors contribute to the pathogenesis of human tegumentary leishmaniasis. Polymorphism within populations of Leishmania from the same species has been documented; indicating that infection with different strains may lead to distinct clinical pictures and can also interfere in the response to treatment. Moreover, detection of parasite genetic tags for the precise identification of strains will improve diagnostics and therapy against leishmaniasis. On the host side, while a predominant Th1 type immune response is important to control parasite growth, it does not eradicate Leishmania and, in some cases, does not prevent parasite dissemination. Evidence has accumulated showing the participation of CD4+ and CD8+ T cells, as well as macrophages, in the pathology associated with L. braziliensis, L. guayanensis, and L. major infection. The discovery that a large percentage of individuals that are infected with Leishmania do not develop disease will help to understand how the host controls Leishmania infection. As these individuals have a weaker type 1 immune response than patients with cutaneous leishmaniasis, it is possible that control of parasite replication in these individuals is dependent, predominantly, on innate immunity, and studies addressing the ability of neutrophils, macrophages, and NK cells to kill Leishmania should be emphasized.
登录
查看更多内容
DOI：
10.4049/jimmunol.181.9.6473
发表时间：
2008-11-01
期刊：
Journal of immunology (Baltimore, Md. : 1950)
影响因子：
--
作者：
Carvalho LP;Pearce EJ;Scott P
通讯作者：
Scott P
影响因子：
5.5
作者：
Afonso, Lilian;Borges, Valeria M.;Brodskyn, Claudia I.
通讯作者：
Brodskyn, Claudia I.
影响因子：
6.4
作者：
Castellucci, Lea;Menezes, Eliane;Carvalho, Edgar M.
通讯作者：
Carvalho, Edgar M.
影响因子：
4.4
作者：
Antonelli, LRV;Dutra, WO;Gollob, KJ
通讯作者：
Gollob, KJ
影响因子：
4.4
作者：
Aseffa, A;Gumy, A;Tacchini-Cottier, F
通讯作者：
Tacchini-Cottier, F