Low computed tomography coronary artery calcium scores in familial longevity: the Leiden Longevity Study.
Low computed tomography coronary artery calcium scores in familial longevity: the Leiden Longevity Study.
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低计算机断层扫描冠状动脉钙评分与家族长寿相关：莱顿长寿研究。
DOI：
10.1007/s11357-014-9668-6
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发表时间：
2014
期刊：
影响因子：
--
通讯作者：
de Craen, Antonius J. M.
中科院分区：
文献类型：
--
作者：
Kroft, Lucia J. M.;van der Bijl, Noortje;van der Grond, Jeroen;Altmann-Schneider, Irmhild;Slagboom, Pieternella E.;Westendorp, Rudolf G. J.;de Roos, Albert;de Craen, Antonius J. M.
长寿父母的后代在中年时心血管疾病的患病率较低。这项研究的目的是调查后代与对照组相比的钙评分，并确定心血管危险因素的影响。对长寿家系(n = 2 44，男性12 5)及其配偶(n = 2 2 3，男性96)的后代进行CT冠状动脉钙化评分，并以此作为对照。对不同性别的钙质评分分别进行分析。受试者按极低钙评分≤10分和10分以上分组。采用非参数曼氏检验、卡方检验和Logistic回归分析来确定钙评分、家族寿命和心血管危险因素之间的关系。与对照组相比，更多长寿父母的后代钙水平较低。在男性中，34%的子女的≤得分为10，而对照组的得分为21%(优势比(OR)和95%的可信区间(CI)2.0，1.08-3.7，p = 0.028)。在女性中，70%的子女≤得分为10，而对照组为54.5%(OR1.9，95%可信区间1.13-3.4p = 0.019)。在对年龄(男性，p = 0.043和女性，p = 0.003)进行校正并对女性的主要危险因素进行进一步校正后，差异仍然显著，这表明较低的钙评分受遗传因素的影响。在男性中，这种联系被发现受到心血管风险因素的影响。有长寿倾向的男性和女性的冠状动脉钙化评分低于对照组。低分值可能表明较年轻的生物动脉年龄与心血管疾病发生的低风险相关。
Offspring of long-lived parents have a low prevalence of cardiovascular disease in middle age. The purposes of this study were to investigate calcium scores in offspring as compared to controls and to determine the influence of cardiovascular risk factors. CT coronary artery calcium score was measured in offspring of long-lived families (n = 244, 125 males) and their partners (n = 223, 96 males) who served as controls. Calcium scores were analyzed separately for sexes. Subjects were grouped by very low calcium score ≤10 and scores above 10. Nonparametric Mann-Whitney test, chi-squared tests, and logistic regression analyses were performed to determine the association between calcium scores, familial longevity, and cardiovascular risk factors. More offspring of long-lived parents had lower calcium scores than controls. In men, 34 % of offspring had score ≤10 versus 21 % of controls (odds ratio (OR) and 95 % confidence interval (CI) 2.0, 1.08–3.7, p = 0.028). In women, 70 % of offspring had score ≤10 versus 54 % of controls (OR 1.9, 95 % CI 1.13–3.4, p = 0.019). Differences remained significant after correction for age (men, p = 0.043 and women, p = 0.003) and further correction for major risk factors in women, indicating genetic influence for lower calcium scores. In men, the association was found to be influenced by cardiovascular risk factors. Men and women with a familial propensity to become long-lived have lower coronary artery calcium scores than controls. Low scores may indicate a younger biologic arterial age associated with a low risk for incident cardiovascular disease.
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作者：
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