Nanoparticles for Targeted Drug Delivery to Cancer Stem Cells and Tumor.
Nanoparticles for Targeted Drug Delivery to Cancer Stem Cells and Tumor.
复制标题
用于癌症干细胞和肿瘤靶向药物输送的纳米颗粒。
DOI：
10.1007/978-1-4939-8661-3_6
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发表时间：
2018
期刊：
影响因子：
--
通讯作者：
He,Xiaoming
中科院分区：
文献类型：
--
作者：
Wang,Hai;He,Xiaoming
由于肿瘤干细胞（CSCs）的耐药性，纳米粒药物递送系统靶向递送多种药物对CSCs和肿瘤的杀伤潜力巨大。在这一章中，我们描述了多层pH响应性聚合物纳米颗粒（NP）的制备，通过多次纯化来封装多种亲水性和疏水性治疗诊断剂，用于控制和顺序释放。透明质酸（HA）不仅用于主动靶向CSC以降低它们由于休眠而产生的耐药性（即，缓慢代谢），而且还替代常用的聚（乙烯醇）（PVA）作为稳定剂来合成纳米颗粒。
Due to the drug resistance of cancer stem cells (CSCs), CSC-targeted delivery of multiple drugs in nanoparticle-based drug delivery system holds great potential for the destruction of the CSCs and Tumor. In this chapter, we describe the preparation of multi-layered pH-responsive polymeric nanoparticles (NPs) by multiple emulsifications to encapsulate multiple hydrophilic and hydrophobic theranostic agents for controlled and sequenced release. Hyaluronic acid (HA) is used for not only actively targeting the CSCs to reduce their drug resistance due to dormancy (i.e., slow metabolism), but also replacing the commonly used poly (vinyl alcohol) (PVA) as a stabilizing agent to synthesize the nanoparticles.
影响因子：
4.9
作者：
Hai Wang;Shuting Zhao;P. Agarwal;J. Dumbleton;Jianhua Yu;Xiongbin Lu;Xiaoming He
通讯作者：
Hai Wang;Shuting Zhao;P. Agarwal;J. Dumbleton;Jianhua Yu;Xiongbin Lu;Xiaoming He