Plasma glycocalicin. An aid in the classification of thrombocytopenic disorders.
Plasma glycocalicin. An aid in the classification of thrombocytopenic disorders.
复制标题
血浆糖运载蛋白。
DOI：
10.1056/nejm198710223171701
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发表时间：
1987
期刊：
影响因子：
--
通讯作者：
Coller,BS
中科院分区：
文献类型：
--
作者：
Steinberg,MH;Kelton,JG;Coller,BS
在一些血小板减少症患者中，很难确定这种情况是由血小板生成不足（巨核细胞数量减少）还是其破坏率增加（正常或巨核细胞数量增加）引起的。一个非侵入性的测试，以帮助区分这两种类型的血小板减少症将是useful.We相关的血小板膜糖蛋白lb的片段，血小板减少症的机制，通过评估骨髓巨核细胞含量和测量血小板寿命的血浆浓度glycocalicin。用血小板糖蛋白Ib的糖帽蛋白成分的单克隆抗体测定血浆糖帽蛋白。34名健康对照者的糖帽蛋白平均血浆浓度为合并正常血浆浓度的87± 20%（范围：52%~ 127%）。通过检查骨髓（所有患者）和测定自体血小板寿命（6例患者）证实的所有8例再生障碍性贫血或无巨核细胞性血小板减少症患者的glycocalicin水平显著低于正常范围（5%至27%）。相比之下，25名血小板减少症患者被认为是由血小板寿命缩短引起的，他们的骨髓中含有正常或增加数量的巨核细胞，他们的glycocalicin水平在正常范围内或高于正常范围（48%至261%）。这些研究表明，血浆glycocalicin的测量可能是一个有用的辅助分类血小板减少性疾病。（N Engl J Med 1987; 317：1037-42.）
In some patients with thrombocytopenia, it is difficult to determine whether the condition is caused by underproduction of platelets (reduced numbers of megakaryocytes) or an increase in the rate of their destruction (normal or increased numbers of megakaryocytes). A noninvasive test to help distinguish between these two categories of thrombocytopenia would be useful.We related the plasma concentration of glycocalicin, a fragment of the platelet-membrane glycoprotein lb, to the mechanism of thrombocytopenia by evaluating bone marrow megakaryocyte content and measuring platelet life span. Plasma glycocalicin was measured with a monoclonal antibody to the glycocalicin component of platelet glycoprotein lb.The mean (±SD) plasma concentration of glycocalicin in 34 healthy controls was 87±20 percent of the level in pooled normal plasma (range, 52 to 127 percent). All of eight patients with aplastic anemia or amegakaryocytic thrombocytopenia confirmed by examining bone marrow (in all patients) and by determining the life span of autologous platelets (in six patients) had glycocalicin levels significantly below the normal range (5 to 27 percent). In contrast, each of 25 patients with thrombocytopenia thought to be caused by a reduction in platelet life span, whose bone marrow contained normal or increased numbers of megakaryocytes, had glycocalicin levels that fell within or above the normal range (48 to 261 percent). There was no overlap of values between the two patient populations.These studies indicate that the measurement of plasma glycocalicin may be a useful adjunct in classifying thrombocytopenic disorders. (N Engl J Med 1987; 317:1037–42.)
影响因子：
2.9
作者：
SNYDER, EL;MOROFF, G;HEATON, A
通讯作者：
HEATON, A
糖运载蛋白在正常血浆中循环的证据。
DOI：
10.1172/jci111273
发表时间：
1984
期刊：
The Journal of clinical investigation
影响因子：
--
作者：
Coller,BS;Kalomiris,E;Steinberg,M;Scudder,LE
通讯作者：
Scudder,LE
DOI：
10.1016/0005-2736(80)90102-9
发表时间：
1980
期刊：
Biochimica et biophysica acta
影响因子：
--
作者：
N. Solum;I. Hagen;C. Filion;Torun Stabaek
通讯作者：
Torun Stabaek