Ethnic disparities in demographic, clinicopathologic and biological behaviours and prognosis of gastric cancer in northwest China.
Ethnic disparities in demographic, clinicopathologic and biological behaviours and prognosis of gastric cancer in northwest China.
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中国西北地区胃癌人口统计学、临床病理学和生物学行为及预后的种族差异。
DOI：
10.1002/cam4.3551
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发表时间：
2020-12
期刊：
影响因子：
4
通讯作者：
Chen Z
中科院分区：
文献类型：
--
作者：
Cao J;Chen J;Zhang Q;Wu J;Wang W;Zhang X;Zhao D;Zhang Q;Yang W;Chen Z
本回顾性研究旨在调查中国胃癌高发地区胃癌（GC）的人口统计学、临床病理和生物学行为的民族差异。GC患者5022例，其中汉族3987例（79.4%），回族987例（14.4%）。所有患者数据均检索自2009年至2017年。使用Kaplan - Meier方法估计中位生存期，并使用log - rank检验进行比较。采用Cox比例风险模型评估协变量的影响。同样，回族和汉族的5年生存率都很低（分别为23.8%和24.2%）。与汉族患者相比，T1期、0期或肿瘤<5 cm的回族患者预后不良风险分别增加2.144倍、1.426倍和1.305倍（均p < 0.05）。此外，在Ki67、EGFR和VEGF高表达人群中，回族患者的预后不良风险分别是汉族患者的1.265倍、1.364倍和1.401倍（均p < 0.05）。西北地区胃癌患者预后存在民族差异。了解种族对胃癌的影响将指导合理的预后评估和未来的干预措施，以使中国不同种族的胃癌患者获得平等的高质量护理。据我们所知，这是第一个研究来自中国胃癌发病率最高的地区之一的5022名胃癌（GC）患者中两个主要中国民族之间的种族差异的研究；这是首个评估中国两个民族胃癌预后相关生物学标志物的研究。这些知识可以为为这些人群服务的医生和公共卫生专家提供重要信息，以改善治疗和结果。
This retrospective study aimed to investigate ethnic disparities in demographic, clinicopathologic, and biological behaviours of gastric cancer (GC) in a high GC incidence area of China. There were 5022 GC patients, including 3987 Han (79.4%) and 987 Hui (14.4%) patients from Northwest China. All patient data were retrieved from 2009 to 2017. Median survival was estimated using the Kaplan‐Meier method and compared using the log‐rank test. A Cox proportional hazards model was used to assess the impact of covariates. Similarly, low 5‐year OS rates were observed in both the Hui and Han groups (23.8% and 24.2% respectively). Hui patients with stage T1 or N0 or with tumours <5 cm had 2.144‐fold, 1.426‐fold and 1.305‐fold increased risks of poor prognosis compared with Han patients with these characteristics respectively (all p < 0.05). Further, Hui patients had 1.265‐fold, 1.364‐fold and 1.401‐fold increased risks of poor prognosis compared with Han patients among those with high expression of Ki67, EGFR and VEGF respectively (all p < 0.05). There are ethnic disparities in the prognosis of GC patients in Northwest China. Understanding the effects of ethnicity on GC will guide reasonable evaluations of prognosis and future interventions to equalise access to high‐quality care for GC patients of different ethnicities in China. To our knowledge, this is the first study to examine the ethnic disparity between two main Chinese ethnic groups among 5022 gastric cancer (GC) patients from one of the highest GC incidence areas of China; the first study to assess the relevant biologic markers associated with GC prognosis between two Chinese ethnic groups. This knowledge can provide important information to both physicians and public health experts serving these populations to improve treatment and outcomes.
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影响因子：
6.2
作者：
Fang CY;Tseng M
通讯作者：
Tseng M
影响因子：
0.7
作者：
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通讯作者：
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作者：
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通讯作者：
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作者：
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通讯作者：
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影响因子：
7.4
作者：
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通讯作者：
Saraiya, Mona