Propranolol intervention therapy for infants with facial hemangioma.
Propranolol intervention therapy for infants with facial hemangioma.
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DOI：
10.5114/wo.2012.31774
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发表时间：
2012
期刊：
影响因子：
--
通讯作者：
Zhang A
中科院分区：
文献类型：
--
作者：
Meng J;Li Z;Gu Q;Zhang J;Zhuang Q;Si Y;Zhang A
本研究旨在评价小剂量心得安介入治疗增殖期婴幼儿面部血管瘤的临床疗效和不良反应。共入组了22例患者，包括9例男性和13例女性，平均年龄为5.5个月。这些患者被诊断为面部血管瘤。在住院的第一周，要求患者根据体重服用普萘洛尔（1.0 mg/kg至1.5 mg/kg，每日一次）。出院后，要求患者持续服用普萘洛尔，并每两周重新评估一次。观察治疗过程，记录血管瘤的大小、颜色、质地等信息，处理治疗过程中的不良反应，评价心得安的临床疗效。服用心得安后24 h血管瘤颜色消退。经过3个月~ 9个月的观察，临床疗效Ⅰ级0例，Ⅱ级2例，Ⅲ级13例，Ⅳ级7例。有效率100%。22例患者心率较治疗前减慢，2例患者出现轻微腹泻，治疗后消失，整个过程中未出现严重不良反应。小剂量普萘洛尔治疗婴幼儿血管瘤具有副作用小、使用方便、安全、疗效显著等优点，是一种较好的治疗方法。
The current study aimed to evaluate the clinical efficacy and adverse effects of small doses of propranolol intervention therapy for infants with infantile facial hemangioma in the proliferation stage. A total of 22 patients including 9 males and 13 females with an average age of 5.5 months were enrolled. These patients were diagnosed with facial hemangioma. During the first week of hospitalization, the patients were requested to take propranolol according to their weight (1.0 mg/kg to 1.5 mg/kg once daily). After hospital discharge, the patients were requested to take propranolol consistently and were reassessed every two weeks. We closely observed the process, recorded information about the size, color, and texture of the hemangioma, coped with the adverse effect during the treatment, and evaluated the clinical efficacy of propranolol. The color of the hemangioma faded 24 h after taking propranolol. After 3 months to 9 months of observation, we obtained the following clinical efficacies: level I, 0; level II, 2; level III, 13; and level IV, 7. The effective rate was 100%. The heart rate of 22 patients became slower than before treatment, 2 patients had slight diarrhea that disappeared after treatment, and there was no serious adverse effect during the entire process. With the advantages of minor side effects, convenience, safety, and evident efficacy, the administration of small doses of propranolol is a good method for treating hemangioma in infants.
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影响因子：
1.8
作者：
Enjoras, O;Brevière, GM;Leverger, G
通讯作者：
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影响因子：
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影响因子：
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作者：
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通讯作者：
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