Sex differences in sub-anesthetic ketamine's antidepressant effects and abuse liability.
Sex differences in sub-anesthetic ketamine's antidepressant effects and abuse liability.
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DOI：
10.1016/j.cobeha.2018.02.001
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发表时间：
2018-10
影响因子：
5
通讯作者：
Kabbaj M
中科院分区：
文献类型：
--
作者：
Wright KN;Kabbaj M
Sub-anesthetic ketamine produces rapid antidepressant effects in patients with bipolar and unipolar major depression where conventional monoaminergic-based antidepressant drugs have been ineffective or ridden with side effects. A single ketamine infusion can produce antidepressant effects lasting up to two weeks, and multiple ketamine infusions prolong this effect. Pre-clinical studies are underway to uncover ketamine's mechanisms of action, but there are still many questions unanswered regarding the safety of its long-term use. Abuse liability is one area of concern, as recreational ketamine use is an ongoing issue in many parts of the world. Another understudied area is sex differences in responsivity to ketamine. Women are twice as likely as men to be diagnosed with depression, and they progress through stages of drug addiction more rapidly than their male counterparts. Despite this, preclinical studies in ketamine's antidepressant and addictive-like behaviors in females are limited. These intersecting factors in recent clinical and pre-clinical studies are reviewed to characterize ketamine's therapeutic potential, its limitations, and its potential mechanisms of action.
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影响因子：
10.6
作者：
Sarkar A;Kabbaj M
通讯作者：
Kabbaj M
影响因子：
9.3
作者：
Caffino, Lucia;Di Chio, Marzia;Chiamulera, Cristiano
通讯作者：
Chiamulera, Cristiano
影响因子：
11.3
作者：
Romeo, Bruno;Choucha, Walid;Rotge, Jean-Yves
通讯作者：
Rotge, Jean-Yves
DOI：
10.1016/j.pscychresns.2017.09.001
发表时间：
2017-11-30
期刊：
Psychiatry research. Neuroimaging
影响因子：
--
作者：
Li CR;Zhang S;Hung CC;Chen CM;Duann JR;Lin CP;Lee TS
通讯作者：
Lee TS
影响因子：
4.7
作者：
Dossat AM;Wright KN;Strong CE;Kabbaj M
通讯作者：
Kabbaj M