Depression in chronic ketamine users: Sex differences and neural bases.
Depression in chronic ketamine users: Sex differences and neural bases.
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DOI：
10.1016/j.pscychresns.2017.09.001
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发表时间：
2017-11-30
期刊：
影响因子：
--
通讯作者：
Lee TS
中科院分区：
文献类型：
--
作者：
Li CR;Zhang S;Hung CC;Chen CM;Duann JR;Lin CP;Lee TS
长期使用氯胺酮会导致认知和情感缺陷，包括抑郁症。在这里，我们研究了慢性氯胺酮使用者抑郁的性别差异和神经基础。根据流行病学研究中心抑郁量表（CES-D）的评估，与不使用药物的健康对照组（HC）相比，使用氯胺酮的女性（而不是男性）表现出更高的抑郁评分。我们评估了亚属前扣带皮层（sgACC）的静息状态功能连通性（rsFC），这是一个一直与抑郁症发病机制有关的前额叶结构。与HC相比，氯胺酮使用者（KU）在校正阈值下没有表现出sgACC连接的显著变化。然而，在KU中，对CES-D评分的线性回归显示，随着抑郁严重程度的增加，sgACC与眶额叶皮质（OFC）的连通性减少。单独检查，男性和女性KU分别显示双侧颞上回和背内侧前额叶皮层（dmPFC）的sgACC连接更高，与抑郁症相关。sgACC-OFC和sgACC-dmPFC连通性与抑郁的线性相关斜率在KU和HC之间存在显著差异。这些发现强调了慢性氯胺酮使用者中sgACC的rsFC变化与抑郁症和性别差异有关。
Chronic ketamine use leads to cognitive and affective deficits including depression. Here, we examined sex differences and neural bases of depression in chronic ketamine users. Compared to non-drug using healthy controls (HC), ketamine-using females but not males showed increased depression score as assessed by the Center of Epidemiological Studies Depression Scale (CES-D). We evaluated resting state functional connectivity (rsFC) of the subgenual anterior cingulate cortex (sgACC), a prefrontal structure consistently implicated in the pathogenesis of depression. Compared to HC, ketamine users (KU) did not demonstrate significant changes in sgACC connectivities at a corrected threshold. However, in KU, a linear regression against CES-D score showed less sgACC connectivity to the orbitofrontal cortex (OFC) with increasing depression severity. Examined separately, male and female KU showed higher sgACC connectivity to bilateral superior temporal gyrus and dorsomedial prefrontal cortex (dmPFC), respectively, in correlation with depression. The linear correlation of sgACC-OFC and sgACC-dmPFC connectivity with depression was significantly different in slope between KU and HC. These findings highlighted changes in rsFC of the sgACC as associated with depression and sex differences in these changes in chronic ketamine users.
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