The Passage of H(2)O(2) from Chloroplasts to Their Associated Nucleus during Retrograde Signalling: Reflections on the Role of the Nuclear Envelope.
The Passage of H(2)O(2) from Chloroplasts to Their Associated Nucleus during Retrograde Signalling: Reflections on the Role of the Nuclear Envelope.
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DOI：
10.3390/plants11040552
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发表时间：
2022-02-19
期刊：
影响因子：
--
通讯作者：
Mullineaux PM
中科院分区：
文献类型：
--
作者：
Breeze E;Mullineaux PM
叶绿体对不利环境信号的反应，主要是光强度的增加，刺激叶绿体到细胞核的逆行信号传导，从而导致立即保护反应和长期适应的诱导。光合作用过程中产生的过氧化氢（H2O2）被认为可以启动和转导响应光抑制光强度的逆行信号。叶绿体来源的 H2O2 信号转导所实现的信号特异性可能取决于经常观察到的这些细胞器与细胞核的密切关联。在这篇综述中，我们更准确地考虑了附着在细胞核上的叶绿体与 H2O2 穿过叶绿体和核膜双层膜的要求之间密切联系的本质。特别重要的是内质网（ER）与叶绿体有密切的物理接触，并且与核膜相邻。因此，转导 H2O2 分子必须穿过的核周空间可能具有与 ER 腔相同的氧化环境。根据对动物细胞的研究，内质网腔可能是植物细胞中蛋白质氧化折叠产生的 H2O2 的重要来源。如果是这种情况，那么内质网腔/核周空间有可能成为修改叶绿体到细胞核 H2O2 信号转导的重要位置，从而通过其他不同的环境线索引入对其的调节。这些包括例如热应激和病原体感染，它们会诱导未折叠蛋白反应，其特征是内质网腔内 H2O2 水平增加。
The response of chloroplasts to adverse environmental cues, principally increases in light intensity, stimulates chloroplast-to-nucleus retrograde signalling, which leads to the induction of immediate protective responses and longer-term acclimation. Hydrogen peroxide (H2O2), generated during photosynthesis, is proposed to both initiate and transduce a retrograde signal in response to photoinhibitory light intensities. Signalling specificity achieved by chloroplast-sourced H2O2 for signal transduction may be dependent upon the oft-observed close association of a proportion of these organelles with the nucleus. In this review, we consider more precisely the nature of the close association between a chloroplast appressed to the nucleus and the requirement for H2O2 to cross both the double membranes of the chloroplast and nuclear envelopes. Of particular relevance is that the endoplasmic reticulum (ER) has close physical contact with chloroplasts and is contiguous with the nuclear envelope. Therefore, the perinuclear space, which transducing H2O2 molecules would have to cross, may have an oxidising environment the same as the ER lumen. Based on studies in animal cells, the ER lumen may be a significant source of H2O2 in plant cells arising from the oxidative folding of proteins. If this is the case, then there is potential for the ER lumen/perinuclear space to be an important location to modify chloroplast-to-nucleus H2O2 signal transduction and thereby introduce modulation of it by additional different environmental cues. These would include for example, heat stress and pathogen infection, which induce the unfolded protein response characterised by an increased H2O2 level in the ER lumen.
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影响因子：
16.6
作者：
Exposito-Rodriguez M;Laissue PP;Yvon-Durocher G;Smirnoff N;Mullineaux PM
通讯作者：
Mullineaux PM
影响因子：
11.6
作者：
Estavillo, Gonzalo M.;Crisp, Peter A.;Pogson, Barry J.
通讯作者：
Pogson, Barry J.
影响因子：
5.6
作者：
Bobik K;Burch-Smith TM
通讯作者：
Burch-Smith TM
影响因子：
7.2
作者：
Fryer, MJ;Ball, L;Baker, NR
通讯作者：
Baker, NR
DOI：
10.1073/pnas.1010721108
发表时间：
2011-02-15
影响因子：
11.1
作者：
Fomenko, Dmitri E.;Koc, Ahmet;Gladyshev, Vadim N.
通讯作者：
Gladyshev, Vadim N.