The chromatin source-sink hypothesis: a shared mode of chromatin-mediated regulations.
The chromatin source-sink hypothesis: a shared mode of chromatin-mediated regulations.
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DOI：
10.1242/dev.201989
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发表时间：
2023-11-01
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中科院分区：
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我们提出，一些染色质介导的调控过程受源库关系的支配，其中因素作为“源”来生产或提供资源，并相互竞争以占据单独的“库”。在这个模型中，基因组 DNA 的大部分充当“汇”，其中充满了“源”，例如可用的组蛋白变体、组蛋白的共价修饰、这些修饰的阅读器和非编码 RNA。不同来源对库的竞争占用导致分化细胞中基因组平衡的不同状态。在动态发育事件（例如有性生殖）期间，我们提出源库关系的急剧而快速的重新配置会改变染色质状态。我们设想，通过改变汇的尺寸、重新配置现有汇的占用或改变源的大小，可以发生源的重新路由，从而提供一个中心机制来解释大量的表观遗传现象，这些现象有助于表型杂色、合子基因组激活和核仁优势。摘要：在该模型中，细胞编程动力学受源-库关系控制，因此染色质相关因子（“源”）竞争占据基因组 DNA 区域（“库”）。
We propose that several chromatin-mediated regulatory processes are dominated by source-sink relationships in which factors operate as ‘sources’ to produce or provide a resource and compete with each other to occupy separate ‘sinks’. In this model, large portions of genomic DNA operate as ‘sinks’, which are filled by ‘sources’, such as available histone variants, covalent modifications to histones, the readers of these modifications and non-coding RNAs. Competing occupation for the sinks by different sources leads to distinct states of genomic equilibrium in differentiated cells. During dynamic developmental events, such as sexual reproduction, we propose that dramatic and rapid reconfiguration of source-sink relationships modifies chromatin states. We envision that re-routing of sources could occur by altering the dimensions of the sink, by reconfiguration of existing sink occupation or by varying the size of the source, providing a central mechanism to explain a plethora of epigenetic phenomena, which contribute to phenotypic variegation, zygotic genome activation and nucleolar dominance. Summary: A model in which cellular programming dynamics is governed by source-sink relationships, such that chromatin associated factors (‘sources’) compete to occupy regions of genomic DNA (‘sinks’).
影响因子：
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作者：
Francisco FO;Lemos B
通讯作者：
Lemos B