Coordination of autophagy with other cellular activities.
Coordination of autophagy with other cellular activities.
复制标题
自噬与其他细胞活动的协调
DOI：
10.1038/aps.2012.194
复制
发表时间：
2013-05
影响因子：
8.2
通讯作者：
Qin, Zheng-hong
中科院分区：
文献类型：
--
作者：
Wang, Yan;Qin, Zheng-hong
近年来，自噬的细胞生物学现象引起了越来越多的关注，部分原因是其细胞机制的关键成分的发现。自噬在无数细胞功能中起着至关重要的作用。自噬有其自身的调节机制，但这一过程并不是孤立的。自噬与其他细胞活动协调以维持细胞内稳态。自噬对于一系列人类生理过程至关重要。自噬的多功能作用可以通过其与各种细胞途径的几个关键组分相互作用的能力来解释。在这篇综述中，我们重点关注自噬与其他生理过程之间的协调，包括遍在蛋白-蛋白酶体系统（UPS）、能量稳态、衰老、程序性细胞死亡、免疫反应、微生物入侵和炎症。从研究自噬网络中获得的见解应该增加我们对它们在人类疾病中的作用及其作为治疗干预靶点的潜力的理解。
The cell biological phenomenon of autophagy has attracted increasing attention in recent years, partly as a consequence of the discovery of key components of its cellular machinery. Autophagy plays a crucial role in a myriad of cellular functions. Autophagy has its own regulatory mechanisms, but this process is not isolated. Autophagy is coordinated with other cellular activities to maintain cell homeostasis. Autophagy is critical for a range of human physiological processes. The multifunctional roles of autophagy are explained by its ability to interact with several key components of various cell pathways. In this review, we focus on the coordination between autophagy and other physiological processes, including the ubiquitin-proteasome system (UPS), energy homeostasis, aging, programmed cell death, the immune responses, microbial invasion and inflammation. The insights gained from investigating autophagic networks should increase our understanding of their roles in human diseases and their potential as targets for therapeutic intervention.
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影响因子：
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20.1
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