Intensity-modulated radiation therapy for prostate cancer after rectal surgery: a single hospital long-term safety analysis
Intensity-modulated radiation therapy for prostate cancer after rectal surgery: a single hospital long-term safety analysis
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直肠术后前列腺癌调强放射治疗：单家医院长期安全性分析
DOI：
10.1007/s10147-022-02124-w
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发表时间：
2022
影响因子：
3.3
通讯作者：
T. Mizowaki
中科院分区：
文献类型：
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作者：
Shuang Zhang;K. Nakamura;Rihito Aizawa;S. Akamatsu;T. Mizowaki
放射治疗是前列腺癌患者直肠手术后的一种治疗选择；然而，放射治疗对此类患者的毒性尚未阐明。本研究旨在评价前列腺癌直肠手术后调强放射治疗(IMRT)的远期毒性和疗效。我们对2000年1月至2019年12月在我所接受调强放射治疗的直肠手术后前列腺癌患者进行了回顾性分析。计划总剂量70~78Gy2-Gy2次，直肠吻合术的剂量限制在70Gy.观察两组急性和晚期毒性反应及生存结果。分析中包括了20名患者。中位年龄71岁，中位随访期86个月。从手术到调强放疗的中位时间为93.5个月。前列腺特异性抗原值中位数为13.17 ng/ml，总剂量中位数为74GY，直肠吻合最大剂量中位数为66.97GY。8年生化无复发生存率为70.2%，总生存率为90.0%。2级急性泌尿生殖系统和胃肠道毒性发生率分别为14.3%和0%。直肠吻合剂量限制在70Gy时，未观察到 ≥ -3急性或晚期毒性反应。本研究提示前列腺癌患者直肠手术后，如果术后5年以上，Dmax <； 剂量限制在70Gy时，调强放疗可能是安全有效的。
Radiotherapy is a treatment option for prostate cancer patients after rectal surgery; however, the toxicity profile of radiotherapy for such patients has not been elucidated. This study aimed to evaluate the long-term toxicities and efficacy of intensity-modulated radiotherapy (IMRT) in patients with prostate cancer who had undergone rectal surgery. We retrospectively analyzed patients with prostate cancer after rectal surgery, who were definitively treated with IMRT between January 2000 and December 2019 at our institution. The planned total dose was 70–78 Gy in 2-Gy fraction, and the dose to the rectal anastomosis was limited to 70 Gy. The acute and late toxicities and survival outcomes were evaluated. Twenty patients were included in the analysis. The median age was 71 years, with a median follow-up of 86 months. The median time from surgery to IMRT was 93.5 months. The median prostate-specific antigen value was 13.17 ng/ml. The median total dose was 74 Gy, and the median maximum dose to rectal anastomosis was 66.97 Gy. The 8-year biochemical recurrence-free and overall survival rates were 70.2% and 90.0%, respectively. The incidence rates of grade 2 acute genitourinary and gastrointestinal toxicities were 14.3% and 0%, respectively. No grade ≥ 3 acute or late toxicities were observed when the rectal anastomosis dose was limited to 70 Gy. This retrospective analysis suggested that IMRT for patients with prostate cancer after rectal surgery may be safe and effective with rectal dose constraint of Dmax < 70 Gy if more than 5 years have passed after surgery.
DOI：
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发表时间：
2010
期刊：
Journal of the National Comprehensive Cancer Network : JNCCN
影响因子：
--
作者：
J. Mohler;R. Bahnson;B. Boston;J. E. Busby;A. D'Amico;J. Eastham;C. Enke;D. George;E. Horwitz;R. Huben;P. Kantoff;M. Kawachi;M. Kuettel;P. Lange;G. Macvicar;E. Plimack;J. Pow-Sang;M. Roach;E. Rohren;B. Roth;D. Shrieve;Matthew R. Smith;S. Srinivas;P. Twardowski;P. Walsh
通讯作者：
J. Mohler;R. Bahnson;B. Boston;J. E. Busby;A. D'Amico;J. Eastham;C. Enke;D. George;E. Horwitz;R. Huben;P. Kantoff;M. Kawachi;M. Kuettel;P. Lange;G. Macvicar;E. Plimack;J. Pow-Sang;M. Roach;E. Rohren;B. Roth;D. Shrieve;Matthew R. Smith;S. Srinivas;P. Twardowski;P. Walsh
DOI：
10.1016/j.ijrobp.2009.03.078
发表时间：
2010-03-01
影响因子：
7
作者：
Michalski, Jeff M.;Gay, Hiram;Jackson, Andrew;Tucker, Susan L.;Deasy, Joseph O.
通讯作者：
Deasy, Joseph O.