A heart that beats for 500 years: age-related changes in cardiac proteasome activity, oxidative protein damage and expression of heat shock proteins, inflammatory factors, and mitochondrial complexes in Arctica islandica, the longest-living noncolonial animal.
A heart that beats for 500 years: age-related changes in cardiac proteasome activity, oxidative protein damage and expression of heat shock proteins, inflammatory factors, and mitochondrial complexes in Arctica islandica, the longest-living noncolonial animal.
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跳动 500 年的心脏：寿命最长的非殖民动物北极岛动物的心脏蛋白酶体活性、氧化蛋白损伤以及热休克蛋白表达、炎症因子和线粒体复合物与年龄相关的变化。
DOI：
10.1093/gerona/glt201
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发表时间：
2014
期刊：
影响因子：
--
通讯作者：
Sosnowska D
中科院分区：
文献类型：
--
作者：
Sosnowska D
对可忽略的衰老动物的研究可能会提供线索，从而更好地了解心脏衰老过程。为了阐明成功的心脏衰老的机制，我们研究了与年龄相关的变化，蛋白酶体活性，氧化蛋白损伤和热休克蛋白，炎症因子和线粒体复合物的表达在海洋quahogArctica islandica，最长寿的非殖民动物（最大寿命潜力：508年）的心脏。我们发现在A的心脏。氧化损伤蛋白质的胰岛水平在120岁之前没有显著变化。Caspase样和胰蛋白酶样蛋白酶体活性无明显衰老诱导的变化。胰凝乳蛋白酶样蛋白酶体活性在生命早期显著下降，然后保持稳定长达182年。未观察到蛋白质泛素化程度与年龄之间的显著关系。在A的心脏。islandica，早期生活中的HSP 90和五个线粒体电子传递链复合体的表达下降。我们发现，A组大鼠心脏中三种白细胞介素样介质（白细胞介素-6、白细胞介素-1 β和肿瘤坏死因子-α）的表达与年龄相关。islandica。总的来说，在寿命极长的软体动物中，蛋白质稳态的维持可能有助于心脏功能的保护。我们的数据还支持这样一个概念，即心血管系统中的低度慢性炎症是衰老过程的普遍特征，这在无脊椎动物中也很明显。
Study of negligibly senescent animals may provide clues that lead to better understanding of the cardiac aging process. To elucidate mechanisms of successful cardiac aging, we investigated age-related changes in proteasome activity, oxidative protein damage and expression of heat shock proteins, inflammatory factors, and mitochondrial complexes in the heart of the ocean quahogArctica islandica, the longest-lived noncolonial animal (maximum life span potential: 508 years). We found that in the heart ofA. islandicathe level of oxidatively damaged proteins did not change significantly up to 120 years of age. No significant aging-induced changes were observed in caspase-like and trypsin-like proteasome activity. Chymotrypsin-like proteasome activity showed a significant early-life decline, then it remained stable for up to 182 years. No significant relationship was observed between the extent of protein ubiquitination and age. In the heart ofA. islandica, an early-life decline in expression of HSP90 and five mitochondrial electron transport chain complexes was observed. We found significant age-related increases in the expression of three cytokine-like mediators (interleukin-6, interleukin-1β, and tumor necrosis factor-α) in the heart ofA. islandica. Collectively, in extremely long-lived molluscs, maintenance of protein homeostasis likely contributes to the preservation of cardiac function. Our data also support the concept that low-grade chronic inflammation in the cardiovascular system is a universal feature of the aging process, which is also manifest in invertebrates.
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影响因子：
20.1
作者：
Dai DF;Rabinovitch PS;Ungvari Z
通讯作者：
Ungvari Z
影响因子：
3.9
作者：
Kwong, LK;Sohal, RS
通讯作者：
Sohal, RS
极地和温带泥蛤的线粒体老化
影响因子：
5.3
作者：
E. Philipp;H. Pörtner;D. Abele
通讯作者：
D. Abele
DOI：
--
发表时间：
2007
期刊：
--
影响因子：
--
作者：
Z. Ungvari;Zsuzsanna Orosz;N. Labinskyy;Aracelie Rivera;Zhao Xiangmin;Kira E. Smith;A. Csiszar
通讯作者：
Z. Ungvari;Zsuzsanna Orosz;N. Labinskyy;Aracelie Rivera;Zhao Xiangmin;Kira E. Smith;A. Csiszar
影响因子：
9.3
作者：
Dai, Dao-Fu;Rabinovitch, Peter S.
通讯作者：
Rabinovitch, Peter S.