Sex differences in cortical volume and gyrification in autism.
Sex differences in cortical volume and gyrification in autism.
复制标题
DOI：
10.1186/s13229-015-0035-y
复制
发表时间：
2015
期刊：
影响因子：
6.2
通讯作者：
Menon V
中科院分区：
文献类型：
--
作者：
Schaer M;Kochalka J;Padmanabhan A;Supekar K;Menon V
男性占优势是自闭症谱系障碍（ASD）的一个突出特征，据报道男女比例为4：1。由于对男性的压倒性关注，对ASD性别差异的神经解剖学基础知之甚少。调查性别差异与足够的样本量是至关重要的，以提高我们的理解的生物学机制的基础上ASD的女性。我们利用开放获取的自闭症脑成像数据交换（ABIDE）数据集，从53名ASD女性中获得结构性脑成像数据，这些女性与ASD男性的等效样本以及他们的典型发育（TD）男性和女性同龄人相匹配。使用FreeSurfer处理脑图像，以评估局部皮质形态测量的三个关键特征：体积、厚度和脑回化。使用全脑方法来确定性别、诊断和性别与诊断相互作用的显著影响，使用p < 0.01的严格阈值来控制假阳性。进行了稳定性和功效分析，以指导未来对ASD性别差异的研究。我们在双侧上级颞叶皮质中检测到性别的主要影响，这是由于ASD和TD组中女性的皮质体积大于男性。性别与诊断的相互作用被检测到的ventromedial/orbitofrontal前额叶皮层（vmPFC/OFC）的回旋。事后分析显示，与ASD女性以及TD男性和女性相比，ASD男性的vmPFC/OFC回旋减少导致了性别与诊断的相互作用。最后，稳定性分析表明，随着样本量的减少，观察到显著聚类的可能性急剧下降，这表明以前的研究在很大程度上动力不足。例如，对于30名患有ASD的女性的样本（总共n = 120），仅在50%的模拟子样本中检测到显著的性别-诊断相互作用。我们的研究结果表明，典型的性别差异的一些特征保留在ASD患者的大脑中，而其他人则没有。ASD的性别差异与涉及语言和社会功能的皮层区域有关，这是该疾病的两个缺陷领域。稳定性分析提供了新的定量的见解，为什么较小的样本可能以前未能检测到性别差异。本文的在线版本（doi：10.1186/s13229-015-0035-y）包含补充材料，可供授权用户使用。
Male predominance is a prominent feature of autism spectrum disorders (ASD), with a reported male to female ratio of 4:1. Because of the overwhelming focus on males, little is known about the neuroanatomical basis of sex differences in ASD. Investigations of sex differences with adequate sample sizes are critical for improving our understanding of the biological mechanisms underlying ASD in females. We leveraged the open-access autism brain imaging data exchange (ABIDE) dataset to obtain structural brain imaging data from 53 females with ASD, who were matched with equivalent samples of males with ASD, and their typically developing (TD) male and female peers. Brain images were processed with FreeSurfer to assess three key features of local cortical morphometry: volume, thickness, and gyrification. A whole-brain approach was used to identify significant effects of sex, diagnosis, and sex-by-diagnosis interaction, using a stringent threshold of p < 0.01 to control for false positives. Stability and power analyses were conducted to guide future research on sex differences in ASD. We detected a main effect of sex in the bilateral superior temporal cortex, driven by greater cortical volume in females compared to males in both the ASD and TD groups. Sex-by-diagnosis interaction was detected in the gyrification of the ventromedial/orbitofrontal prefrontal cortex (vmPFC/OFC). Post-hoc analyses revealed that sex-by-diagnosis interaction was driven by reduced vmPFC/OFC gyrification in males with ASD, compared to females with ASD as well as TD males and females. Finally, stability analyses demonstrated a dramatic drop in the likelihood of observing significant clusters as the sample size decreased, suggesting that previous studies have been largely underpowered. For instance, with a sample of 30 females with ASD (total n = 120), a significant sex-by-diagnosis interaction was only detected in 50 % of the simulated subsamples. Our results demonstrate that some features of typical sex differences are preserved in the brain of individuals with ASD, while others are not. Sex differences in ASD are associated with cortical regions involved in language and social function, two domains of deficits in the disorder. Stability analyses provide novel quantitative insights into why smaller samples may have previously failed to detect sex differences. The online version of this article (doi:10.1186/s13229-015-0035-y) contains supplementary material, which is available to authorized users.
登录
查看更多内容
影响因子：
5.7
作者：
Fischl, B;Sereno, MI;Dale, AM
通讯作者：
Dale, AM
DOI：
10.1002/ajmg.b.32165
发表时间：
2013-10-01
影响因子：
2.8
作者：
Chang, Shun-Chiao;Pauls, David L.;Santangelo, Susan L.
通讯作者：
Santangelo, Susan L.
影响因子：
11
作者：
Di Martino, A.;Yan, C-G;Li, Q.;Denio, E.;Castellanos, F. X.;Alaerts, K.;Anderson, J. S.;Assaf, M.;Bookheimer, S. Y.;Dapretto, M.;Deen, B.;Delmonte, S.;Dinstein, I.;Ertl-Wagner, B.;Fair, D. A.;Gallagher, L.;Kennedy, D. P.;Keown, C. L.;Keysers, C.;Lainhart, J. E.;Lord, C.;Luna, B.;Menon, V.;Minshew, N. J.;Monk, C. S.;Mueller, S.;Mueller, R. A.;Nebel, M. B.;Nigg, J. T.;O'Hearn, K.;Pelphrey, K. A.;Peltier, S. J.;Rudie, J. D.;Sunaert, S.;Thioux, M.;Tyszka, J. M.;Uddin, L. Q.;Verhoeven, J. S.;Wenderoth, N.;Wiggins, J. L.;Mostofsky, S. H.;Milham, M. P.
通讯作者：
Milham, M. P.
DOI：
10.1111/j.2044-835x.2011.02042.x
发表时间：
2012-06-01
影响因子：
2.3
作者：
Eriksson, Marten;Marschik, Peter B.;Gallego, Carlos
通讯作者：
Gallego, Carlos
影响因子：
5.7
作者：
Dale, AM;Fischl, B;Sereno, MI
通讯作者：
Sereno, MI