The Association between the ALDH2 rs671 Polymorphism and Athletic Performance in Japanese Power and Strength Athletes.
The Association between the ALDH2 rs671 Polymorphism and Athletic Performance in Japanese Power and Strength Athletes.
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DOI：
10.3390/genes13101735
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发表时间：
2022-09-27
期刊：
影响因子：
3.5
通讯作者：
Kikuchi, Naoki
中科院分区：
文献类型：
--
作者：
Saito, Aoto;Saito, Mika;de Almeida, Kathleen Y.;Homma, Hiroki;Deguchi, Minoru;Kozuma, Ayumu;Kobatake, Naoyuki;Okamoto, Takanobu;Nakazato, Koichi;Kikuchi, Naoki
关键词：
rs671 多态性与乙醛脱氢酶 2 (ALDH2) 的酶活性相关，在东亚人中，该酶活性被 A 等位基因削弱。我们最近报道了这种多态性与运动人群的运动状态和非运动人群的肌肉力量的关联。因此，我们假设 ALDH2 rs671 多态性与力量/力量运动员的表现之间存在关联。我们的目的是阐明 ALDH2 rs671 多态性与力量/力量运动员表现之间的关系。研究对象包括 253 名力量/力量运动员（167 名男性和 86 名女性）和 721 名健康对照者（303 名男性和 418 名女性）。力量/力量运动员分为经典举重（n = 84）和举重（n = 169）。在举重运动员中，未观察到 ALDH2 rs671 多态性的基因型和等位基因频率存在差异，以及成绩与 ALDH2 rs671 基因型之间的关联。然而，GA + AA 基因型举重运动员总记录的单位体重相对值低于 GG 基因型举重运动员（7.1 ± 1.2 vs. 7.8 ± 1.0；p = 0.010，部分 η2 = 0.08）。我们的结果共同表明 ALDH2 rs671 多态性在举重运动员力量表现中的作用。
The rs671 polymorphism is associated with the enzymatic activity of aldehyde dehydrogenase 2 (ALDH2), which is weakened by the A allele in East Asians. We recently reported the association of this polymorphism with the athletic status in athletic cohorts and the muscle strength of non-athletic cohorts. Therefore, we hypothesized the association of ALDH2 rs671 polymorphism with the performance in power/strength athletes. We aimed to clarify the relationship between the ALDH2 rs671 polymorphism and performance in power/strength athletes. Participants comprising 253 power/strength athletes (167 men and 86 women) and 721 healthy controls (303 men and 418 women) were investigated. The power/strength athletes were divided into classic powerlifting (n = 84) and weightlifting (n = 169). No differences in the genotypes and allele frequencies of the ALDH2 rs671 polymorphism and an association between performance and the ALDH2 rs671 genotype were observed in weightlifters. However, the relative values per body weight of the total record were lower in powerlifters with the GA + AA genotype than those with the GG genotype (7.1 ± 1.2 vs. 7.8 ± 1.0; p = 0.010, partial η2 = 0.08). Our results collectively indicate a role of the ALDH2 rs671 polymorphism in strength performance in powerlifters.
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影响因子：
3.7
作者：
Chung HC;Keiller DR;Roberts JD;Gordon DA
通讯作者：
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影响因子：
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作者：
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DOI：
10.1016/b978-0-12-816193-7.00014-2
发表时间：
2019-01-01
期刊：
SPORTS, EXERCISE, AND NUTRITIONAL GENOMICS: CURRENT STATUS AND FUTURE DIRECTIONS
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作者：
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通讯作者：
Ahmetov, Ildus I.
影响因子：
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通讯作者：
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影响因子：
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作者：
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通讯作者：
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