SRC-1 and Twist1 expression positively correlates with a poor prognosis in human breast cancer.
SRC-1 and Twist1 expression positively correlates with a poor prognosis in human breast cancer.
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DOI：
10.7150/ijbs.8193
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发表时间：
2014
影响因子：
9.2
通讯作者：
Jiang J
中科院分区：
文献类型：
--
作者：
Xu Y;Hu B;Qin L;Zhao L;Wang Q;Wang Q;Xu Y;Jiang J
为了评价类固醇受体辅活化子-1(SRC-1)和Twist1在乳腺癌组织中的表达对乳腺癌预后的可能价值，我们用免疫组织化学方法检测了137例乳腺癌标本中SRC-1和Twist1的表达。所有患者术后平均随访5年。生存曲线用Kaplan-Meier法绘制。采用COX比例风险回归模型进行多因素分析，以评估预后价值。结果表明，SRC-1和Twist1在蛋白水平的表达呈正相关(P<；0.001)。SRC-1和HER2的表达呈正相关(P=0.024)。Twist1蛋白表达与淋巴结转移呈正相关(P<；0.001)，与PR状态呈负相关(P=0.041)。SRC-1或Twist1阳性表达患者的总生存期(OS)和无病生存期(DFS)均低于SRC-1或Twist1阴性表达患者(P<；0.05)。此外，SRC-1阴性/Twist1阴性患者的OS和DFS最好(P<；0.01)。多因素生存分析显示，sRC-1表达、肿瘤分期和PR是影响OS的独立预后因素(P值分别为0.019、0.001和0.02)，Twist1表达、淋巴结状况和PR是影响DFS的独立因素(P值分别为0.006、0.001和0.029)。这些结果表明，SRC-1/Twist1的联合表达状态可以改善乳腺癌患者的预后判断。
To evaluate the possible prognostic value of Steroid Receptor Coactivator-1 (SRC-1) and Twist1 expression in human breast cancer, we examined SRC-1 and Twist1 expression using immunohistochemistry on tissue microarray sections containing 137 breast cancer specimens. All patients were followed up for a median of 5 years following surgery. Survival curves were generated using the Kaplan-Meier method. Multivariate analysis was performed using the Cox proportional hazard regression model to assess the prognostic values. The results showed a positive correlation between SRC-1 and Twist1 expression at protein levels (P < 0.001). Also, SRC-1 expression positively correlated with HER2 expression (P = 0.024). The protein expression of Twist1 positively associated with lymph node metastasis (P < 0.001), but inversely correlated with PR status (P = 0.041). Patients with SRC-1 or Twist1-positive expression exhibited poorer overall survival (OS) and disease-free survival (DFS) than did those with SRC-1 or Twist1-negative expression (P < 0.05 for all). In addition, SRC-1-negativeive/Twist1-negative patients had the best OS and DFS (P < 0.01 for both). In multivariate survival analysis, SRC-1 expression, tumor stage, and PR were found to be independent prognostic factors related to OS (P = 0.019, < 0.001 and 0.02, respectively) and Twist1 expression, lymph node status and PR were independent predictors of DFS (P = 0.006, 0.001 and 0.029, respectively). These results suggest that a combined SRC-1/Twist1 expression status could improve the prognostic judgment for breast cancer patients.
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影响因子：
3.8
作者：
Soini Y;Tuhkanen H;Sironen R;Virtanen I;Kataja V;Auvinen P;Mannermaa A;Kosma VM
通讯作者：
Kosma VM
DOI：
10.1186/bcr3317
发表时间：
2012-09-11
期刊：
Breast cancer research : BCR
影响因子：
--
作者：
Riaz M;Sieuwerts AM;Look MP;Timmermans MA;Smid M;Foekens JA;Martens JW
通讯作者：
Martens JW
影响因子：
3.4
作者：
Fleming, FJ;Myers, E;Young, LS
通讯作者：
Young, LS
影响因子：
254.7
作者：
MCGUIRE, WL;CLARK, GM
通讯作者：
CLARK, GM
影响因子：
11.5
作者：
Redmond, Aisling M.;Bane, Fiona T.;Young, Leonie S.
通讯作者：
Young, Leonie S.