Transcription factors zeb1, twist and snai1 in breast carcinoma.
Transcription factors zeb1, twist and snai1 in breast carcinoma.
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DOI：
10.1186/1471-2407-11-73
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发表时间：
2011-02-16
期刊：
影响因子：
3.8
通讯作者：
Kosma VM
中科院分区：
文献类型：
--
作者：
Soini Y;Tuhkanen H;Sironen R;Virtanen I;Kataja V;Auvinen P;Mannermaa A;Kosma VM
上皮间充质转化（EMT）是癌细胞获得成纤维细胞特征并因此能够侵入邻近组织的过程。转录因子zeb 1、snai 1和twist调节EMT。我们用免疫组织化学方法研究了zeb 1、twist和snai 1在大量乳腺癌中的肿瘤和间质中的表达。将结果与患者的雌激素和孕激素受体状态、HER 2扩增、分级、组织学、TNM状态和生存进行比较。twist的核表达见于3.6%的上皮肿瘤细胞室，snai 1的核表达见于3.1%的病例，而zeb 1在这些区域完全未检测到。与此相反，肿瘤间质隔室显示核zeb 1和twist表达的情况下，分别为75%和52.4%。尽管罕见，但上皮肿瘤细胞区室中twist的核表达与患者的不良结局相关（p = 0.054对数秩，p = 0.013，Breslow，p = 0.025 Tarone-Ware）。snai 1、zeb 1或twist在间质区室中的表达没有任何预后意义。此外，这些因素与肿瘤的大小无关，也与腋窝或远处转移的存在无关。zeb 1和twist在间质室中的表达与肿瘤的阳性雌激素或孕激素受体状态呈正相关。间质zeb 1表达显着低于导管原位癌比浸润性癌（p = 0.020）。髓样癌（p = 0.017）和粘液癌（p = 0.009）的zeb 1间质表达低于导管癌。间质扭曲表达也低于粘液性（p = 0.017）比导管癌。转录因子zeb 1和twist的表达主要发生在乳腺癌的间质室中，可能代表两个细胞群体; EMT转化的肿瘤细胞和基质成纤维细胞由于肿瘤产生的生长因子而活化zeb 1和twist。然而，twist的上皮表达与不良预后相关，暗示其在乳腺癌扩散中的重要性。
Epitheliomesenchymal transition (EMT) is the process where cancer cells attain fibroblastic features and are thus able to invade neighboring tissues. Transcriptional factors zeb1, snai1 and twist regulate EMT. We used immunohistochemistry to investigate the expression of zeb1, twist and snai1 in tumor and stromal compartments by in a large set of breast carcinomas. The results were compared with estrogen and progesterone receptor status, HER2 amplification, grade, histology, TNM status and survival of the patients. Nuclear expression for twist was seen in the epithelial tumor cell compartment in 3.6% and for snai1 in 3.1% of the cases while zeb1 was not detected at all in these areas. In contrast, the tumor stromal compartment showed nuclear zeb1 and twist expression in 75% and 52.4% of the cases, respectively. Although rare, nuclear expression of twist in the epithelial tumor cell compartment was associated with a poor outcome of the patients (p = 0.054 log rank, p = 0.013, Breslow, p = 0.025 Tarone-Ware). Expression of snai1, or expression of zeb1 or twist in the stromal compartment did not have any prognostic significance. Furthermore, none of these factors associated with the size of the tumors, nor with the presence of axillary or distant metastases. Expression of zeb1 and twist in the stromal compartment was positively associated with a positive estrogen or progesterone receptor status of the tumors. Stromal zeb1 expression was significantly lower in ductal in situ carcinomas than in invasive carcinomas (p = 0.020). Medullary carcinomas (p = 0.017) and mucinous carcinomas (p = 0.009) had a lower stromal expression of zeb1 than ductal carcinomas. Stromal twist expression was also lower in mucinous (p = 0.017) than in ductal carcinomas. Expression of transcriptional factors zeb1 and twist mainly occur in the stromal compartment of breast carcinomas, possibly representing two populations of cells; EMT transformed neoplastic cells and stromal fibroblastic cells undergoing activation of zeb1 and twist due to growth factors produced by the tumor. However, epithelial expression of twist was associated with a poor prognosis, hinting at its importance in the spread of breast carcinoma.
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影响因子：
3.8
作者：
Matsuo N;Shiraha H;Fujikawa T;Takaoka N;Ueda N;Tanaka S;Nishina S;Nakanishi Y;Uemura M;Takaki A;Nakamura S;Kobayashi Y;Nouso K;Yagi T;Yamamoto K
通讯作者：
Yamamoto K
Twist1介导的阿霉素诱导的上皮-间质转化与乳腺癌细胞的多药耐药性和侵袭潜力相关
影响因子：
11.5
作者：
Li, Qing-Quan;Xu, Jing-Da;Xu, Zu-De
通讯作者：
Xu, Zu-De
DOI：
10.1186/1756-9966-28-158
发表时间：
2009-12-21
期刊：
Journal of experimental & clinical cancer research : CR
影响因子：
--
作者：
Sasaki K;Natsugoe S;Ishigami S;Matsumoto M;Okumura H;Setoyama T;Uchikado Y;Kita Y;Tamotsu K;Sakamoto A;Owaki T;Aikou T
通讯作者：
Aikou T
影响因子：
50.5
作者：
Shibata, K.;Kajiyama, H.;Kikkawa, F.
通讯作者：
Kikkawa, F.
影响因子：
4
作者：
Hipp, Susanne;Walch, Axel;Becker, Karl-Friedrich
通讯作者：
Becker, Karl-Friedrich