Bidirectional relationship between cardiac extracellular matrix and cardiac cells in ischemic heart disease.
Bidirectional relationship between cardiac extracellular matrix and cardiac cells in ischemic heart disease.
复制标题
DOI：
10.1002/stem.3445
复制
发表时间：
2021-12
期刊：
影响因子：
--
通讯作者：
Davis ME
中科院分区：
文献类型：
--
作者：
Park HJ;De Jesus Morales KJ;Bheri S;Kassouf BP;Davis ME
缺血性心脏病（IHD），包括心肌梗死和心肌病，是世界范围内死亡率和发病率的主要原因。心脏源性干细胞和祖细胞已显示出作为IHD治疗药物的前景，但受到细胞存活率低、保留有限和快速洗脱的限制。解决这一问题的一种机制是将细胞包封在基质或三维构建体中，以便在施用期间提供结构支撑并更好地模拟细胞的生理微环境。更具体地说，细胞外基质（ECM），天然的细胞支持网络，一直是一个强有力的候选人，用于这一目的。此外，有一个强烈的共识，即ECM及其驻留细胞，包括心脏干细胞，在响应组织发育，衰老，疾病进展和修复中具有恒定的相互作用。当受到外部刺激时，细胞和ECM一起工作，通过最初改变ECM的组成和硬度来相互维持局部稳态，这反过来又改变了细胞反应和行为。鉴于这种持续的相互作用，了解双向细胞-ECM相互作用的机制对于开发更好的细胞植入基质以增强细胞植入和心脏组织修复至关重要。本文综述了目前在该领域的理解，阐明心肌细胞外基质和驻留细胞之间的信号转导机制，响应IHD的发病。此外，这篇综述强调了天然ECM模拟心脏基质作为调节心脏细胞行为和诱导心脏修复的平台的最新进展。
Ischemic heart diseases (IHDs), including myocardial infarction and cardiomyopathies, are a leading cause of mortality and morbidity worldwide. Cardiac-derived stem and progenitor cells have shown promise as a therapeutic for IHD but are limited by poor cell survival, limited retention, and rapid washout. One mechanism to address this is to encapsulate the cells in a matrix or three-dimensional construct, so as to provide structural support and better mimic the cells’ physiological microenvironment during administration. More specifically, the extracellular matrix (ECM), the native cellular support network, has been a strong candidate for this purpose. Moreover, there is a strong consensus that the ECM and its residing cells, including cardiac stem cells, have a constant interplay in response to tissue development, aging, disease progression, and repair. When externally stimulated, the cells and ECM work together to mutually maintain the local homeostasis by initially altering the ECM composition and stiffness, which in turn alters the cellular response and behavior. Given this constant interplay, understanding the mechanism of bidirectional cell-ECM interaction is essential to develop better cell implantation matrices to enhance cell engraftment and cardiac tissue repair. This review summarizes current understanding in the field, elucidating the signaling mechanisms between cardiac ECM and residing cells in response to IHD onset. Furthermore, this review highlights recent advances in native ECM-mimicking cardiac matrices as a platform for modulating cardiac cell behavior and inducing cardiac repair.
登录
查看更多内容
DOI：
10.1186/1755-1536-5-15
发表时间：
2012-09-03
期刊：
Fibrogenesis & tissue repair
影响因子：
--
作者：
Fan D;Takawale A;Lee J;Kassiri Z
通讯作者：
Kassiri Z
影响因子：
4.3
作者：
French, Kristin M.;Maxwell, Joshua T.;Davis, Michael E.
通讯作者：
Davis, Michael E.
影响因子：
3.5
作者：
Grover GN;Rao N;Christman KL
通讯作者：
Christman KL
影响因子：
20.1
作者：
Hatzistergos KE;Quevedo H;Oskouei BN;Hu Q;Feigenbaum GS;Margitich IS;Mazhari R;Boyle AJ;Zambrano JP;Rodriguez JE;Dulce R;Pattany PM;Valdes D;Revilla C;Heldman AW;McNiece I;Hare JM
通讯作者：
Hare JM
DOI：
10.1016/j.jtcvs.2018.07.117
发表时间：
2019-04
期刊：
The Journal of thoracic and cardiovascular surgery
影响因子：
--
作者：
Gaffey AC;Chen MH;Trubelja A;Venkataraman CM;Chen CW;Chung JJ;Schultz S;Sehgal CM;Burdick JA;Atluri P
通讯作者：
Atluri P